Study of cytokine signaling: the quest for immunomodulatory drugs interacting with cytokine production and activity

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Tadashi Kasahara

Abstract

I have been engaged in research and education in the fields of immunology and biochemistry at a medical college and college of pharmacy for 40 years. The original reasons why I began studying cytokines and some of the interests that have motivated me to continue working in the field of cytokine research are described: 1) the roles of cytokines in various immunological and inflammatory diseases (e.g., chemokines in bacterial infections and inflammatory diseases, particularly the role of interleukin-5 and eotaxins in eosinophilia); 2) the role of focal adhesion kinase in antiapoptosis and metastasis of melanoma; 3) recent findings on the role of JAK2/STAT pathways, particularly how JAK2V617F mutation induces dysregulated proliferation and tumorigenesis; and 4) the interactions of various chemical compounds and natural products in cytokine gene activation and signaling. Previous discoveries and published findings by my research group are described, along with comments and discussion pertaining to recent developments in the field.

References

May 18, 1992·Journal of Immunological Methods·Y KoT Kasahara
Jan 1, 1990·Microbiology and Immunology·H TsunodaK Onozaki
Apr 25, 1986·Nucleic Acids Research·Y FurutaniS Nakamura
Apr 29, 1983·Journal of Immunological Methods·H HaradaT Kawai
Mar 1, 1982·The Journal of Experimental Medicine·M HowardW E Paul
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Feb 13, 1997·Biochemical and Biophysical Research Communications·H YamadaK Ito
Jan 22, 1998·Biochemical and Biophysical Research Communications·Y SonodaS Watanabe
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T OdaN Mukaida
Feb 22, 2001·Biochemical and Biophysical Research Communications·Y SonodaT Kasahara
Apr 27, 2001·Biochemical and Biophysical Research Communications·M FunakoshiT Kasahara
Jun 11, 2002·Biochemical and Biophysical Research Communications·Shinya SakuraiTadashi Kasahara
Sep 7, 2002·Antioxidants & Redox Signaling·Tadashi KasaharaYoshiko Sonoda
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taiko OdaTadashi Kasahara
Nov 7, 2002·Biochemical and Biophysical Research Communications·Hongyan DongKouji Matsushima
May 16, 2003·The Journal of Biological Chemistry·Megumi Funakoshi-TagoTadashi Kasahara
Jul 9, 2004·Biochimica Et Biophysica Acta·Yoshiko SonodaTadashi Kasahara
Nov 2, 2004·Biological & Pharmaceutical Bulletin·Ryoko UtsuboTadashi Kasahara
Jan 24, 2006·International Immunopharmacology·Sachiko MatsuiTadashi Kasahara
Oct 24, 2006·Biochemical and Biophysical Research Communications·Daiju IchikawaTadashi Kasahara

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