Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam

Pulmonary Medicine
Sy Duong-QuyAnh-Tuan Dinh-Xuan

Abstract

The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO2 (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for...Continue Reading

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Citations

May 10, 2017·Upsala Journal of Medical Sciences·Alexandra ThornadtssonMarieann Högman
Aug 30, 2019·Medicina·Panaiotis FinamoreRaffaele Antonelli Incalzi
Sep 25, 2019·Journal of Breath Research·Tuomas Karvonen, Lauri Lehtimäki
May 29, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Sy Duong-QuyTimothy J Craig
Jun 5, 2020·Current Medicinal Chemistry·Lauri LehtimäkiMarieann Högman

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Software Mentioned

SPSS
Expair
CANO

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