Study of eye drops dispensing and dose variability by using plastic dropper tips

Drug Development and Industrial Pharmacy
Z Sklubalová, Z Zatloukal

Abstract

The application of eye drops from flexible dropper bottles fitted with different types of dropper tips is associated with the high variability of eye drop weights. The aim of this report was to investigate the simultaneous effect of three factors influencing the mean weight of drops dispensing from two plastic dropper tips. Using a designed experiment (Box-Behnken), the effect of the concentration of benzalkonium chloride solutions (BAC) in the range of 0-0.02%, the dispensing angle from 90 degrees to 30 degrees from horizontal, and the residual volume of liquid in the dropper bottle from 4 to 10 mL on the mean drop weights were examined. The significant effect of the increase in BAC concentration resulted in a linear decrease in drop weights for both of the dropper tips investigated. The significant effect of the dispensing angle was influenced by the dropper tip design. For the dropper tip A, the effect of the dropper tip tilt was described by the quadratic equation with a minimum, which corresponded to the dispensing angle equal to that of 48 degrees from horizontal. Below this angle, the increase in drop weights occurred due to the drop formation from the wetted external surface of the tip orifice. The linear decrease in dr...Continue Reading

References

Jun 15, 1986·American Journal of Ophthalmology·C M Lederer, R E Harold
Apr 15, 1985·American Journal of Ophthalmology·R H BrownE B Davis
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·L Van Santvliet, A Ludwig
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L Van Santvliet, A Ludwig
Mar 9, 1999·Experimental Eye Research·J C PanditJ M Tiffany
Mar 5, 2004·Survey of Ophthalmology·Luc Van Santvliet, Annick Ludwig

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Citations

Mar 5, 2009·Pharmacy World & Science : PWS·Hanni Prihhastuti PuspitasariInes Krass
Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Bruce I GaynesYevgeniva Sorokin
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ana Guzman-AranguezJesús Pintor
Oct 30, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maryam AliMark E Byrne
Jun 28, 2017·BMC Ophthalmology·Jee Myung YangKyung Chul Yoon
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Lyndon JonesMark Willcox

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