Study of factor VII, tissue factor pathway inhibitor and monocyte tissue factor in noninsulin-dependent diabetes mellitus

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Eman A El-GhorouryShadia Ragab

Abstract

Changes in plasma tissue factor (TF)-activated factor VII (FVIIa) and plasma tissue factor pathway inhibitor (TFPI) in type II diabetes mellitus are assessed, vascular complicated and noncomplicated patients compared, and whether these novel hemostatic activity markers predict vascular complications in diabetic patients, improving risk assessment, is determined. Fifty type II diabetic patients and 20 healthy controls (age, sex and body mass matched) underwent medical history and examination, fasting plasma glucose level, glycosylated hemoglobin (HbA1c), lipid profile, hemostatic parameters, plasma TF activity, and TFPI and TF expression on blood monocytes. Mean TF, TF activity, TFPI, and FVIIa significantly increased among hyperlipidemic compared with normolipidemic diabetic patients, and normolipidemic diabetic patients compared with controls. Mean percentage TF-positive monocytes with and without lipopolysaccharide, plasma TF activity, TFPI and FVIIa were significantly higher among complicated than noncomplicated diabetic patients. Mean percentage TF-positive monocytes without and with lipopolysaccharide, plasma TF activity, plasma TFPI and FVIIa were higher among diabetic patients with macrovascular compared with microvascul...Continue Reading

References

Jan 1, 1997·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M ZumbachP P Nawroth
Mar 22, 2001·Journal of Diabetes and Its Complications·M E Carr
Nov 3, 2001·Journal of the American College of Cardiology·J I OsendeJ P Crandall
Mar 9, 2004·Yonsei Medical Journal·Kyung Soon Song, Hyun Kyung Kim
Sep 29, 2005·Diabetes Research and Clinical Practice·Sora LudwigGarry X Shen
Nov 5, 2005·Thrombosis and Haemostasis·Deborah D MottonJohn C Rutledge
Dec 24, 2005·Journal of Thrombosis and Haemostasis : JTH·D W SommeijerH ten Cate

❮ Previous
Next ❯

Citations

Apr 18, 2002·Thrombosis Research·Sedat KirazMeral Calgüneri
Aug 25, 2011·Thrombosis Research·C E HenrikssonP Kierulf
May 9, 2009·Journal of Thrombosis and Haemostasis : JTH·J-G WangN Mackman
Oct 23, 2009·Clinical Science·Alexander BreitensteinFelix C Tanner
Jan 24, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Vibeke BratsethIngebjørg Seljeflot

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.