Study of genes associated with the 'anger-in' and 'anger-out' emotions of humans using a rat model

Experimental and Therapeutic Medicine
Yinghui GuoMingqi Qiao

Abstract

The aim of the present study was to investigate the genes associated with 'anger-in' (tendency to suppress anger) and 'anger-out' (tendency to express anger through verbal or physical means) emotions in humans. Wistar rats were divided into five groups (n=10/group), based on the type of model and the Chinese medicinal formulation administered, and the rat models were established. The five groups were as follows: Normal control (control), anger-in model (AIM), anger-in Jingqianshu-administered (AIA), anger-out model (AOM) and anger-out Jingqianping-administered (AOA). Open-field, resident-intruder and aggressive behavior tests were carried out, as well as gene expression analysis, reverse transcription-quantitative polymerase chain reaction and western blot analyses. The body weights of the rats in the AIM and AOM groups were significantly lower than those of the control group rats. The open-field test indicated that the scores in the AOM group were significantly higher (P<0.05) than those in the AIM group. The aggression scores of the rats in the AOM group were significantly higher than those of the AIM group rats. Jingqianshu and Jingqianping granules attenuated the behavioral changes of the rats. 5-Htr2C, GABA B R2 and 5-Htr3...Continue Reading

References

Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pierre Blier
Jun 11, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marcelo Páez-Pereda
Apr 17, 2007·Current Opinion in Neurobiology·Daniel Ulrich, Bernhard Bettler
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lan WangZhu Chen
Apr 22, 2009·Epidemiologia e psichiatria sociale·Ronald C KesslerPhilip S Wang
Mar 5, 2014·European Heart Journal·Elizabeth MostofskyMurray A Mittleman

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Methods Mentioned

BETA
chip
PCR

Software Mentioned

SmartView
GeneSpring
SPSS
GeneChip Operating

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