Study of Genetic Association With DCDC2 and Developmental Dyslexia in Hong Kong Chinese Children

Clinical Practice and Epidemiology in Mental Health : CP & EMH
Mary M Y WayeConnie S-H Ho

Abstract

Doublecortin domain-containing 2 (DCDC2) is a doublecortin domain-containing gene family member and the doublecortin domain has been demonstrated to bind to tubulin and enhance microtubule polymerization. It has been associated with developmental dyslexia and this protein family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. The objective of the study is to find out if there is any association of genetic variants of DCDC2 with developmental dyslexia in Chinese children from Hong Kong. The dyslexic children were diagnosed as developmental dyslexia (DD) using the Hong Kong Test of Specific Learning Difficulties in Reading and Writing (HKT-SpLD) by the Department of Health, Hong Kong. Saliva specimens were collected and their genotypes of DCDC2 were studied by DNA sequencing or TaqMan Real Time PCR Assays. The most significant marker is rs6940827 which is associated with DD with nominal p-value (0.011). However, this marker did not remain significant after multiple testing corrections and the adjusted p-value from permutation test was 0.1329. Using sliding window haplotype analysis, several haplotypes were found to be nominally associated with DD. The smallest nominal p valu...Continue Reading

References

Oct 14, 1994·Science·L R CardonJ C DeFries
Jan 23, 1999·American Journal of Human Genetics·J GayánJ C DeFries
Jul 21, 2000·Journal of the International Neuropsychological Society : JINS·K A FlanneryJ Schultz
Feb 24, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·E L Grigorenko
Apr 16, 2002·American Journal of Human Genetics·D E KaplanJ R Gruen
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elena L GrigorenkoDavid Pauls
Sep 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mikko TaipaleJuha Kere
Jan 9, 2004·Cognition·Connie Suk-Han HoVivian Hui Luan
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haiying MengJeffrey R Gruen
Jan 30, 2007·Brain Research Bulletin·Steven W ThrelkeldR Holly Fitch
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wai Ting SiokLi Hai Tan
Sep 24, 2008·Journal of Neural Transmission·Kerstin U LudwigPer Hoffmann
Feb 25, 2009·Annals of Dyslexia·A WilckeP Ahnert
Nov 3, 2010·Behavior Genetics·Haiying MengJeffrey R Gruen
Dec 25, 2010·Autism Research : Official Journal of the International Society for Autism Research·Elad LererRichard P Ebstein
Apr 5, 2011·Biological Psychiatry·Tom S ScerriSilvia Paracchini
May 24, 2011·Behavioral and Brain Functions : BBF·Cadmon K P LimMary M Y Waye
Sep 2, 2011·Psychiatric Genetics·Cecilia MarinoJeffrey R Gruen
Feb 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Caitlin E SzalkowskiR Holly Fitch
Apr 21, 2012·Neuroscience and Biobehavioral Reviews·Maaike VandermostenPol Ghesquière
Nov 28, 2012·Genes, Brain, and Behavior·S MascherettiC Marino
Dec 12, 2012·Molecular Neurobiology·Rong ZhongXiaoping Miao
May 17, 2013·Journal of Human Genetics·Shyamala K VenkateshNallur B Ramachandra
Jun 12, 2013·American Journal of Human Genetics·Natalie R PowersJeffrey R Gruen
Jun 14, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cecilia MarinoDaniela Perani
Jul 13, 2014·Behavioral and Brain Functions : BBF·Cadmon King-Poo LimMary Mui-Yee Waye
Apr 29, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tracy Michelle CentanniMichael P Kilgard
Jul 28, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristiina TammimiesPeter Swoboda
Aug 9, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sara MascherettiCecilia Marino

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Citations

Apr 11, 2019·British Journal of Nursing : BJN·Claire Ford

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Methods Mentioned

BETA
genotyping

Software Mentioned

UNPHASED
HKT
SpLD
AddVal
Haploview

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