Study of genetic prediabetic south Indian subjects. Importance of hyperinsulinemia and beta-cell dysfunction

Diabetes Care
C SnehalathaV Viswanathan

Abstract

To study 1) whether abdominal adiposity was present in adult offspring of two NIDDM parents, 2) whether abdominal adiposity was associated with the development of glucose intolerance, and 3) the association of pancreatic beta-cell function with impaired glucose tolerance (IGT) and NIDDM in these groups. One hundred offspring whose parents both had NIDDM were studied (60 men, 40 women, mean age 34 +/- 6.9 years, BMI 27.4 +/- 4.1 kg/m2). None had a history of glucose intolerance. Nondiabetic control subjects with no family history of diabetes were also studied for comparison (21 men, 19 women, age 36 +/- 10.3 years, BMI 26 +/- 3.7 kg/m2). A standard oral glucose tolerance test was done for all, and plasma glucose, C-peptide, and insulin responses were measured. Abdominal fat measurements at L4-L5 were made using a computed axial tomography scan. Subcutaneous fat (SF), visceral fat (VF), and total fat (TF) areas were measured and VF/SF ratio was calculated. An index of insulin secretion (delta I/G) was derived as the ratio of incremental insulin at 30 min divided by 30-min plasma glucose. IGT was detected in 32 offspring and diabetes in 21 offspring. Diabetic men had a higher TF area than the other groups. SF, VF, and VF/SF ratios...Continue Reading

Citations

Oct 12, 2000·Diabetes Research and Clinical Practice·W R Lee
Aug 17, 2010·Diabetes Technology & Therapeutics·Edavan P PraveenAriachery C Ammini
Mar 1, 2000·Clinical Obstetrics and Gynecology·J Uvena-Celebrezze, P M Catalano
Dec 17, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·M A BethelUNKNOWN NAVIGATOR Study Group
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Dec 14, 2019·Therapeutic Advances in Endocrinology and Metabolism·Jit SarkarPartha Chakrabarti

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