Study of Grape Polyphenols by Liquid Chromatography-High-Resolution Mass Spectrometry (UHPLC/QTOF) and Suspect Screening Analysis

Journal of Analytical Methods in Chemistry
Riccardo FlaminiLuigi Bavaresco

Abstract

Suspect screening analysis is a targeted metabolomics method in which the identification of compounds relies on specific available information, such as their molecular formula and isotopic pattern. This method, coupled to liquid chromatography-high-resolution mass spectrometry, is effective in the study of grape metabolomics, in particular for characterization of flavonols, stilbene derivatives, and anthocyanins. For identification of compounds expected in the samples, a new database of putative compounds was expressly constructed by using the molecular information on potential metabolites of grape and wine from the literature and other electronic databases. Currently, this database contains around 1,100 compounds. The method allows identification of several hundred grape metabolites with two analyses (positive and negative ionization modes), and performing of data reprocessing using "untargeted" algorithms also provided the identification of some flavonols and resveratrol trimers and tetramers in grape for the first time. This approach can be potentially used in the study of metabolomics of varieties of other plant species.

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Citations

Oct 9, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirko De RossoRiccardo Flamini
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Olivas-AguirreAbraham Wall-Medrano
Sep 16, 2017·Journal of the Science of Food and Agriculture·Luca BrillanteDiego Tomasi
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Saleh AlseekhFernando Carrari
Aug 22, 2017·Frontiers in Plant Science·Rakesh KumarAnirudh Kumar
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun Woo KimYoung-Won Chin
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandros TzachristasCharalampos Proestos
Aug 20, 2021·Food Chemistry·Jéssica Bassetto CarraMarcela Maria Baracat

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