PMID: 8586973Nov 15, 1995Paper

Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides

Journal of Inorganic Biochemistry
R P BonomoG Tabbí

Abstract

Copper(II) complexes with LL or LD dipeptides, tripeptides, L-aminoacylamides, or N,N'-bis(aminoacyl)alcanediamine were studied in their reaction with hydrogen peroxide by ESR spectroscopy. Shifts in the magnetic parameters g parallel and A parallel or differences in the quenching percentages of the ESR signal intensity, due to the formation of copper(I) species, suggested that the decomposition mechanism of H2O2 proceeds through the formation of a five-coordinated adduct and a subsequent electron transfer. This last process gave rise to a decomposition process which involved not only H2O2, but also the ligand coordinated to copper. It was surprising to find that, at the longest interaction time, this decomposition reaction always produced a similar copper(II) complex with g = 2.330 +/- 0.005 and A = 164 +/- 4 x 10(-4) cm-1 in spite of the different ligands. Voltammetric measurements confirmed what had been seen by ESR spectroscopy, and suggested that the decomposition mechanism did not involve the formation of copper(III) species. Furthermore, the only copper(II) complex with diastereoisomeric dipeptides, which was able to promote the copper oxidation, was that formed by LL- or LD- Ala-Trp, thus suggesting that d-pi interactio...Continue Reading

References

Aug 15, 1989·Biochemical and Biophysical Research Communications·C J Reed, K T Douglas
Jan 1, 1989·Free Radical Research Communications·P Tachon
Jan 1, 1989·Free Radical Biology & Medicine·H C Sutton, C C Winterbourn
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Citations

Oct 25, 2003·Chemosphere·Pradeep VermaFrantisek Nerud
May 26, 2001·Journal of Inorganic Biochemistry·M Jezowska-BojczukW Bal
Dec 18, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Raffaele P BonomoLaura I Vagliasindi
Dec 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Elżbieta JankowskaTeresa Kowalik-Jankowska
Oct 16, 2001·Chemical Research in Toxicology·M Jezowska-BojczukW Meyer-Klaucke

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