Study of Hemolysis During Storage of Blood in the Blood Bank of a Tertiary Health Care Centre

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Sayeedul Hasan ArifGhazala Mehdi

Abstract

The aim of RBC storage system in a blood bank is to counteract damage to the metabolic machinery and the membrane, to improve post-transfusion viability. In recent years, the need for strict control over the quality of blood has been emphasised. Such quality indicator includes extend of hemolysis and morphological changes of RBC during storage. This study was design to see extend of hemolysis and level of plasma lactate dehydrogenase (LDH) and plasma potassium, during processing and storage at different intervals under blood bank condition. Forty-six donors were selected and blood units were collected and stored under blood bank conditions. Mean plasma haemoglobin of stored blood was estimated by tetra methyl benzidine method (TMB) and percentage hemolysis was calculated on day 0, 1, 7, 21, 28, 35 and 42 days. Similarly plasma LDH and plasma potassium level was also assessed during storage. It was noted that free haemoglobin level and percentage hemolysis progressively increased with storage along with the level of LDH and potassium. However, extend of hemolysis did not exceed the permissible limit of 0.8% up to 42 days of storage. 15 blood bags which showed visual hemolysis on day 28 did not exceeded the threshold of 0.8% hemo...Continue Reading

References

Aug 1, 1967·The Journal of Physiology·R Whittam, J S Wiley
Mar 1, 1982·Transfusion·J T LathamF L Weirich
Jan 15, 2002·Transfusion Medicine Reviews·Samuel O Sowemimo-Coker
Nov 5, 2002·Transfusion Medicine Reviews·John R Hess, Tibor G Greenwalt
Mar 20, 2008·Anesthesia and Analgesia·Hugh M SmithJuraj Sprung
Apr 13, 2010·Blood Transfusion = Trasfusione Del Sangue·Angelo D'AlessandroLello Zolla
May 17, 2011·Asian Journal of Transfusion Science·R N MakrooN L Rosamma
Jul 1, 2007·Asian Journal of Transfusion Science·R B SawantP T Kadam
Feb 24, 2016·BioMed Research International·Ibrahim MustafaTameem Hadwan

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