Study of human papillomavirus infection in patients with anal squamous carcinoma

Diseases of the Colon and Rectum
P S RamanujamM J Fietz

Abstract

The purpose of this study was to determine the incidence of human papillomavirus deoxyribonucleic acid (HPV DNA) in anal squamous carcinoma. HPV DNA in situ hybridization for HPV Types 6, 11, 16, 18, 31, 33, and 35 was performed on the formalin-fixed, paraffin-embedded tissue from 53 perianal and anal squamous carcinomas and 10 controls. HPV DNA sequences were identified in 18 of 53 anal squamous carcinomas (34 percent). All 10 controls were negative for HPV DNA. Of the 18 positive patients, 10 were perianal squamous carcinomas, and 8 were anal canal squamous carcinomas. Six of the perianal carcinomas were positive for HPV Types 6 and 11. The remaining four perianal carcinomas and all eight of the anal canal carcinomas were positive for HPV Types 16 and 18. HPV DNA sequences can be identified in anal squamous carcinomas. Anal squamous epithelium is another site where HPV infection may carry a risk for malignant transformation. One-third of anal squamous carcinomas may be associated with prior HPV infection. Patients with anogenital HPV infection should be routinely screened for anal squamous lesions.

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Citations

May 27, 1999·Diseases of the Colon and Rectum·S R NadalM B Speranzini
Aug 2, 2001·Clinics in Dermatology·M M Bagheri, B Safai
Aug 1, 1997·Journal of Clinical Pathology·P Tilston
Nov 4, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Volker Wienert
Oct 14, 2010·Infectious Agents and Cancer·Sonia RamamoorthyJohn M Carethers
Jul 30, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Mónica MoralesJordi Garcia-Mas

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