Study of interaction between human serum albumin and three phenanthridine derivatives: fluorescence spectroscopy and computational approach

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jianming LiuXiaoge Li

Abstract

Over the past decades, phenanthridine derivatives have captured the imagination of many chemists due to their wide applications. In the present work, the interaction between phenanthridine derivatives benzo [4,5]imidazo[1,2-a]thieno[2,3-c]quinoline (BTQ), benzo[4,5]imidazo[1,2-a]furo[2,3-c]quinoline (BFQ), 5,6-dimethylbenzo[4,5]imidazo[1,2-a]furo[2,3-c]quinoline (DFQ) and human serum albumin (HSA) were investigated by molecular modeling techniques and spectroscopic methods. The results of molecular modeling simulations revealed that the phenanthridine derivatives could bind on both site I in HSA. Fluorescence data revealed that the fluorescence quenching of HSA by phenanthridine derivatives were the result of the formation of phenanthridine derivatives-HSA complex, and the binding intensity between three phenanthridine derivatives and HSA was BTQ>BFQ>DFQ. Thermodynamics confirmed that the interaction were entropy driven with predominantly hydrophobic forces. The effects of some biological metal ions and toxic ions on the binding affinity between phenanthridine derivatives and HSA were further examined.

References

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Jul 25, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhanfen ChenChanglin Liu

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Citations

Nov 3, 2015·Organic & Biomolecular Chemistry·Bo WangHegui Gong
Dec 17, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Yan-Mei HuangHui Li
Aug 5, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Keerti M Naik, Sharanappa T Nandibewoor
Apr 29, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Ayşe ÖzdemirTurgay Tekinay
Jun 22, 2016·Journal of Fluorescence·Shahabuddin MemonMiraç Ocak
Sep 2, 2016·Journal of Agricultural and Food Chemistry·Li ZengDeming Gong
Oct 30, 2016·Journal of Biomolecular Structure & Dynamics·Ting RenJunbiao Chang
Nov 5, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Mohammad Fahimul Hassan, Abdul Rauf
Sep 16, 2017·Journal of Biomolecular Structure & Dynamics·Nuriye AkbayElmas Gökoğlu
Feb 16, 2018·Journal of Biomolecular Structure & Dynamics·Hamid TanzadehpanahMassoud Saidijam
Jun 26, 2018·Journal of Fluorescence·Lusheng WangWangsuo Wu
Feb 25, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·Suma K Pawar, Seetharamappa Jaldappagari
Jun 5, 2020·Journal of Fluorescence·Ruopei SunWangsuo Wu
Jul 1, 2018·International Journal of Biological Macromolecules·Saranya RTamil Selvi A

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