Study of interaction between nitric oxide and ACE activity in STZ-induced diabetic rats: role of insulin

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ali M SharifiBagher Larijani

Abstract

The precise mechanisms of vascular diseases in patients with insulin-dependent diabetes mellitus (IDDM) are not clearly understood. There are evidences of alteration in mechanisms involved in regulating vascular tone including increased ACE activity and decreased NO production in STZ diabetic rats. Insulin treatment may reverse these changes by an unknown mechanism. This study sought to examine the interaction of ACE activity and NO and how insulin treatment affected these mechanisms. Four groups of eight male Sprauge-Dawely rats including control (C) and three diabetic groups (D, IT and LIT) were used in this study. Diabetes induced by injection of 60 mg kg(-1) STZ i.p. After induction of diabetes IT group treated with insulin (10 units kg(-1) daily s.c.) for 4 weeks. LIT group received the same amount of insulin and N(omega)-nitro-l-arginine methyl ester (L-NAME; 20 mg kg(-1) i.p.) for the same period. The D group was diabetic control that treated with saline. ACE activity was determined by HPLC method. At the end of study in D group ACE activity was increased in aorta, heart, lung and serum but Serum NO(x) (nitrate and nitrite) concentration decreased compared to C group. These values were reversed to normal by insulin treat...Continue Reading

Citations

Dec 23, 2008·The Journal of Pharmacology and Experimental Therapeutics·Dale S EdgertonThomas R Strack
May 2, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ali M SharifiMaryam Ghaderpanahi
May 10, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Fernanda A RonchiDulce E Casarini
Sep 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dale S EdgertonAlan D Cherrington

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