PMID: 8961173Nov 1, 1996Paper

Study of interaction effects of polyacrylic acid polymers (carbopol 940) on antimicrobial activity of methyl parahydroxybenzoate against some gram-negative, gram-positive bacteria and yeast

The Journal of Pharmacy and Pharmacology
M ScalzoF Cerreto

Abstract

Cosmetic or pharmaceutical formulations containing hydrophilic polymers of natural or synthetic origin, may be more exposed to successful microbial contamination because of a polymer-preservative interaction. The experimental data reported in this paper relate to the possible interference of Carbopol 940 with methyl parahydroxybenzoate. Results show that this hydrophilic polymer, widely employed in many formulations, exerts, on the contrary, an interesting synergism on microbicidal activity of the preserving agent against E. coli and P. Aeruginosa. A reduction in microbicidal activity against S. aureus and C. albicans is observed for a polymer concentration higher than that needed for anti-Gram-negative synergy.

References

Apr 1, 1957·Journal of the American Pharmaceutical Association·W J TILLMAN, R KURAMOTO

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Citations

Oct 22, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M G SoniG A Burdock
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·C ValentaA Bernkop-Schnürch
Jan 1, 2014·Journal of Pharmaceutics·Onkar SinghAmit K Goyal

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