Study of kinetic parameters in a mechanistic model for bioethanol production through a screening technique and optimization

Bioprocess and Biosystems Engineering
Rafael Ramos de AndradeA C Costa

Abstract

The accurate description of the kinetics and robust modeling of biotechnological processes can only be achieved by incorporating reliable methodologies to easily update the model when there are changes in operational conditions. The purpose of this work is to provide a systematic approach with which to perform model parameters screening and updating in biotechnological processes. Batch experiments are performed to develop a mechanistic model, considering the effect of temperature on the kinetics, and further experiments (batch fermentations using sugar cane molasses from a different harvest) are used to validate the effectiveness of screening before parameters updating. The reduction in the number of kinetic parameters to be re-estimated enabled by the screening procedure reduces significantly the complexity of the optimization, which makes the updating procedure to be significantly quicker, while resulting in accurate performance of the updated model.

References

Apr 20, 2002·Applied Biochemistry and Biotechnology·D I AtalaF Maugeri
Oct 20, 2005·Journal of Bioscience and Bioengineering·N YoshidaK Ogawa
May 15, 2008·Applied Biochemistry and Biotechnology·Rafael Ramos de AndradeRubens Maciel Filho
Feb 1, 1987·Biotechnology and Bioengineering·A DouradoY Sevely
Mar 15, 1993·Biotechnology and Bioengineering·H N ChangB S Kim
Aug 5, 2009·Micron : the International Research and Review Journal for Microscopy·Luciana Borges RetamosoOrlando Motohiro Tanaka

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Citations

Mar 12, 2013·Bioprocess and Biosystems Engineering·João Moreira NetoAline Carvalho da Costa
Jan 15, 2013·Bioresource Technology·Rafael Ramos de AndradeAline Carvalho da Costa
Oct 29, 2014·Bioprocess and Biosystems Engineering·Tao WangJingqi Yuan

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