Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Dushani L PalliyaguruRafael de Cabo

Abstract

Aging is associated with functional and metabolic decline and is a risk factor for all noncommunicable diseases. Even though mice are routinely used for modeling human aging and aging-related conditions, no comprehensive assessment to date has been conducted on normative mouse aging. To address this gap, the Study of Longitudinal Aging in Mice (SLAM) was designed and implemented by the National Institute on Aging (NIA/NIH) as the mouse counterpart to the Baltimore Longitudinal Study of Aging (BLSA). In this manuscript, we describe the premise, study design, methodologies, and technologies currently employed in SLAM. We also discuss current and future study directions. In this large population mouse study, inbred C57BL/6J and outbred UM-HET3 mice of both sexes are longitudinally evaluated for functional, phenotypic, and biological health, and collection of biospecimens is conducted throughout their life span. Within the longitudinal cohorts, a cross-sectional arm of the study has also been implemented for the well-controlled collection of tissues to generate a biorepository. SLAM and studies stemming from SLAM seek to identify and characterize phenotypic and biological predictors of mouse aging and age-associated conditions, exa...Continue Reading

References

Jul 1, 1990·Journal of Gerontology·J L FozardL J Brant
Jul 10, 1987·Science·J W Rowe, R L Kahn
Feb 1, 1955·Journal of Chronic Diseases·N W SHOCK
Dec 1, 1964·The Gerontologist·N W SHOCK
Sep 24, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Birgit KittelUNKNOWN NACAD Group
Sep 24, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Gerd MorawietzUNKNOWN NACAD Group
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
May 8, 2007·Journal of the American College of Cardiology·Carmelinda RuggieroLuigi Ferrucci
Aug 10, 2007·Nature Reviews. Cancer·Kristopher K Frese, David A Tuveson
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Luigi Ferrucci
Jan 17, 2009·Philosophy, Ethics, and Humanities in Medicine : PEHM·Niall ShanksJean Greek
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
May 19, 2010·Journal of Neurosurgical Anesthesiology·George BarretoRona G Giffard
Nov 5, 2010·Journal of the American Geriatrics Society·Damian C StanzianoBernard A Roos
Jan 6, 2011·JAMA : the Journal of the American Medical Association·Stephanie StudenskiJack Guralnik
May 7, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gregory E HicksLuigi Ferrucci
Jul 19, 2011·Current Gerontology and Geriatrics Research·Seung-Uk KoLuigi Ferrucci
Oct 15, 2011·Obesity·Lobke M VaanholtJohn R Speakman
Mar 1, 2012·Nature·Yariv KanfiHaim Y Cohen
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Jan 15, 2014·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Mar 19, 2014·Journal of the American Geriatrics Society·Jennifer A SchrackLuigi Ferrucci
Feb 17, 2015·Experimental Gerontology·Joseph B Margolick, Luigi Ferrucci
Feb 18, 2015·Annual Review of Animal Biosciences·Sarah J MitchellRafael de Cabo
Mar 31, 2015·European Journal of Pharmacology·Terry C Burns, Catherine M Verfaillie
Jun 13, 2015·Current Protocols in Mouse Biology·Cheryl L Ackert-BicknellLuanne L Peters
Aug 6, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Warren LadigesDenny Liggitt
Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arlan RichardsonSteven N Austad
Jan 30, 2016·Molecular Brain·Hirotaka ShojiTsuyoshi Miyakawa
Apr 12, 2016·JAMA : the Journal of the American Medical Association·Raj ChettyDavid Cutler
Jun 16, 2016·Cell Metabolism·Steven N Austad, Kathleen E Fischer
Jun 16, 2016·Cell Metabolism·Sarah J MitchellRafael de Cabo
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christin E BurdJames L Kirkland
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Derek M HuffmanSteven N Austad
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John C NewmanNir Barzilai
Jan 18, 2017·Nature Communications·Julie A MattisonRozalyn M Anderson
Jan 18, 2017·Lipids in Health and Disease·Yee Ting LeeGary Tse
Feb 16, 2017·Journal of Cachexia, Sarcopenia and Muscle·Elisa FabbriLuigi Ferrucci
Mar 16, 2017·The New England Journal of Medicine·Manuel Serrano
Mar 17, 2017·GeroScience·Felipe Sierra, Ron Kohanski
May 10, 2017·Nature Reviews. Genetics·Alessandra BreschiRoderic Guigó
Jun 3, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathleen E Fischer, Nicole C Riddle
Jul 28, 2017·Methods in Molecular Biology·Mohamed SlaouiLaurence Fiette
Oct 17, 2017·Physical Medicine and Rehabilitation Clinics of North America·Carlos E Rivera-Tavarez

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Citations

Mar 10, 2021·GeroScience·Eleonora DuregonRafael de Cabo
Sep 12, 2021·Cell Metabolism·Dushani L PalliyaguruRafael de Cabo

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