Study of Microbiomes in Aseptically Collected Samples of Human Breast Tissue Using Needle Biopsy and the Potential Role of in situ Tissue Microbiomes for Promoting Malignancy

Frontiers in Oncology
Shen MengLei Zhang

Abstract

Mounting evidence suggests that changes in microbiome are linked to development of cancer and its aggressiveness. Microbiome profiles in human breast tissue previously presumed to be sterile, have recently been characterized using high-throughput technologies. Recent findings of microbiome variation between benign and malignant disease provides a rationale for exploring microbiomes associated with cancer during tumor progression. We assessed microbiomes of aseptically collected human breast tissue samples in this study, using needle biopsy from patients with benign and malignant tumors of different histological grading, using 16S rRNA gene amplicon sequencing. This is consistent with previous studies, and our results identified distinct microbiome profiles in breast tissues from women with cancer as compared to women with benign breast disease in Chinese cohorts. The enriched microbial biomarkers in malignant tissue included genus Propionicimonas and families Micrococcaceae, Caulobacteraceae, Rhodobacteraceae, Nocardioidaceae, Methylobacteriaceae, which appeared to be ethno-specific. Further, we compared microbiome profiles in malignant tissues of three different histological grades. The relative abundance of family Bacteroidac...Continue Reading

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Citations

May 23, 2020·Nutrition Reviews·Lisa F StinsonDonna T Geddes
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Datasets Mentioned

BETA
SRP154661

Methods Mentioned

BETA
biopsy
amplicon sequencing
PCR
RNA-seq

Software Mentioned

LefSe
QIIME
STAMP
Adonis
Greengenes
PICRUSt )
usearch61
PICRUSt
Phylogenetic Reconstruction of Unobserved States (
Quantitative Insights Into Microbial Ecology ( QIIME

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