Study of novel molecular probe 99mTc-3PRGD2 in the diagnosis of rheumatoid arthritis

Nuclear Medicine Communications
Chao HuangWeibing Miao

Abstract

Angiogenesis in the synovial membrane plays an important role in the pathogenesis of rheumatoid arthritis (RA). Radiolabeled RGD (Arg-Gly-Asp) peptides can be used as a molecular probe in radionuclide imaging to assess angiogenesis noninvasively in vitro and investigate the process of RA to achieve the goal of early diagnosis and monitoring. The main objective of this study is to evaluate the value of RGD peptides conjugate with Tc-radiolabeled, Tc(HYNIC-3PRGD2)(tricine) (TPPTS) (Tc-3PRGD2 in short) in the diagnosis of RA. Tc-3PRGD2 was synthesized using an HYNIC-3PRGD2 lyophilized kit with TcO4 labeling. Biodistribution and planar imaging studies were carried out in an RA rat model. The ankles were marked by arthritis index (AI) scores (from 0-3 score) according to the degree of ankle swelling and the ankle uptake of Tc-3PRGD2 was compared. Immunohistochemical staining was used to test the expression of integrin αvβ3 in the ankle tissue, analyzing the correlation between uptake of Tc-3PRGD2 and receptor expression. Planar imaging of arthritic ankles became visible at 30 min postinjection of Tc-3PRGD2 and was still clear at 6 h postinjection. The AI score increased, along with the uptake of Tc-3PRGD2. A biodistribution study sh...Continue Reading

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References

Apr 22, 1994·Science·P C BrooksD A Cheresh
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
May 26, 1999·Rheumatology·D A Walsh
Mar 31, 2000·Nature Medicine·P Carmeliet
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Oct 9, 2003·Annals of the Rheumatic Diseases·A E Koch
Feb 3, 2005·Journal of the National Cancer Institute·Janet C MillerJames H Thrall
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ambros J BeerMarkus Schwaiger
Sep 27, 2006·Bioorganic & Medicinal Chemistry Letters·Bård IndrevollAlan Cuthbertson
Nov 24, 2006·Molecular Cancer Therapeutics·Weibo CaiXiaoyuan Chen
May 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Laura M KennyEric O Aboagye
Sep 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Brian J McParlandPamela S Cohen
Jun 2, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jiyun ShiShuang Liu
Aug 10, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bing JiaFan Wang
May 7, 2011·Theranostics·Zhaofei LiuXiaoyuan Chen
Aug 30, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Qingjie MaGuoqing Zhao
Apr 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhaohui ZhuFang Li
Jun 19, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yang LiFan Wang
Oct 17, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dan ZhaoYansong Lin
Jan 22, 2013·Clinical Nuclear Medicine·Xiaona JinFang Li

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