Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Jonatas Zeni KlafkePaulo Ricardo Nazário Viecili

Abstract

Atherosclerosis is an inflammatory disease that affects the arterial wall leading to myocardial, cerebral, and peripheral ischemic syndromes. The use of low doses of aspirin inhibits platelet aggregation and inflammation and prevents cardiovascular mortality. However, ASA may produce hemorrhagic events. Thus, several studies have sought new natural compounds to suppress platelet aggregation without causing serious adverse effects. In this sense, this study aims to compare the effects of Campomanesia xanthocarpa plant extract with those of acetylsalicylic acid (ASA) on inflammatory parameters observed in homozygous mice knockout for the low-density lipoprotein receptor (LDLr-KO) treated with a hypercholesterolemic diet. In this study, 28 male LDLr-KO mice were divided into three groups and fed a hypercholesterolemic diet for 4 weeks. Thereafter, the animals that received the hypercholesterolemic diet were treated for 5 days with (1) distilled water, (2) C. xanthocarpa extract, or (3) acetylsalicylic acid. The levels of inflammatory markers were assessed in the blood samples. The gastric tolerability of the animals after oral administration of the treatments was assessed through quantification of the lesions in the gastric mucosa...Continue Reading

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Citations

Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Feb 12, 2019·Journal of Toxicology and Environmental Health. Part a·Joubert Aires De SousaJaqueline Nascimento Picada
Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla Maiara Lopes CardozoKarine de Cássia Freitas
Jun 20, 2020·Genetics and Molecular Biology·Lilian de Oliveira MachadoRubens Onofre Nodari
Jun 7, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Liane Santariano Sant'AnnaCleci Menezes Moreira
Jun 15, 2019·Drug and Chemical Toxicology·Jader B RuchelDaniela B R Leal
Sep 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla Maiara Lopes CardozoKarine de Cássia Freitas
Nov 10, 2020·Phytotherapy Research : PTR·Nirit BernsteinMuhammad Daniyal
Nov 26, 2020·Anais Da Academia Brasileira De Ciências·Eduardo B B CunhaRoberto H Herai

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