Jan 1, 1975

Study of P50 in patients under continuous O2 inhalation and during chronic respiratory acidosis

Le Poumon et le coeur
A Le GroumellecY Duhamel


In vitro, the affinity of Hb for O2 depends on pH and capnia by the intermediate of the 2-3 DPG level, the concentration of which lowers in the case of acidosis and hypercapnia. Thus, an increase in the affinity results, but while Bohr's effect is immediate, on the contrary the 2-3 DPG effect is slow. Authors have verified the importance of this modification by studying the affinity of Hb for O2 thanks to the P50 technique in 15 normal non-smokers subjects and in 10 subjects with compensated or not respiratory acidosis but normally saturated thanks to continuous O2 administration.

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Mentioned in this Paper

Acidosis, Respiratory
Inspiration Function
Carbon Dioxide
Metabolic Acidosis
Hydrogen-Ion Concentration
In Vitro [Publication Type]

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