Study of Preparation and Utility of Suppository Containing Carbamazepine Tablet for Hospital Use in Rabbits

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Isamu MurataI Kanamoto

Abstract

Cancer patients often report a decreased quality of life due to cancer-related pain, especially neuropathic pain, which is difficult to manage and often develops resistance to morphine. Thus a supplementary analgesic can play an important role in the treatment of cancer-related pain. Carbamazepine (CBZ), for example, can be effective, but only if the patient can take medication orally because it is limited to oral administration. In this study we investigated the efficacy of a suppository containing CBZ tablet in hospital preparations. We selected a base for the suppository of either polyethylene glycol (P), Witepsol VOSCO(®) H-15 (H), or Witepsol VOSCO(®) S-55 (S). Six to eight in vitro and in vivo groups were divided randomly based on route of administration and treatment: intravenous (i.v.), per os (p.o.), and intrarectal administration (i.r.) (composed of CBZ powder and tablet formulations, CBZp and CBZt) prepared in either a base of P, H, or S (CBZp/P, CBZp/H, CBZp/S, CBZt/P, CBZt/H, and CBZt/S). The hardness levels of the CBZt suppository group were significantly lower than the CBZp suppository group. The drug release profiles of the CBZt suppository group were high in order of P, H, and S; there were no significant diffe...Continue Reading

References

Dec 1, 1987·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·M SumiN Kaneniwa
Sep 1, 1995·Biological & Pharmaceutical Bulletin·M ShinodaT Nabeshima
Nov 15, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masako IsekiZenjin Morita

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