PMID: 11333475May 3, 2001Paper

Study of renal function in infants diagnosed with renal pyelectasis in the first year of life

Anales españoles de pediatría
J León GonzálezL Fernández González

Abstract

To evaluate glomerular and tubular function in a group of infants diagnosed with pyelectasis. We studied 14 patients diagnosed with renal pelvis dilatation in-utero or during the first year of life. Creatinine concentrations, urinary excretion of calcium, citrate, oxalate, N-acetyl-D-glucosaminidase (NAG), microalbumin and maximum urine osmolality after administration of intranasal desmopressin were determined. The latter three variables were determined at diagnosis and at the end of follow-up. In all patients creatinine levels were normal. In six patients (42.9%) maximum urine osmolality values were abnormal. In four patients NAG/creatinine concentrations were elevated and in another four patients (28.6%) albumin urinary excretion was elevated. These anomalies tended to return to normal but, at the end of the study, three patients (21.4%) showed increased albuminuria and one (7.1%) showed persistently defective renal concentrating capacity. Ten patients showed metabolic urinary anomalies, potentially leading to the formation of stones (isolated hypercalciuria in five [35,7%], hyperoxaluria in two and hypocitraturia in one, and hypercalciuria associated with hyperoxaluria in two). All patients showed normal glomerular function....Continue Reading

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