Study of rubella candidate vaccine based on a structurally modified plant virus

Antiviral Research
Ekaterina TrifonovaOlga Karpova

Abstract

A novel rubella candidate vaccine based on a structurally modified plant virus - spherical particles (SPs) - was developed. SPs generated by the thermal remodelling of the tobacco mosaic virus are promising platforms for the development of vaccines. SPs combine unique properties: biosafety, stability, high immunogenicity and the effective adsorption of antigens. We assembled in vitro and characterised complexes (candidate vaccine) based on SPs and the rubella virus recombinant antigen. The candidate vaccine induced a strong humoral immune response against rubella. The IgG isotypes ratio indicated the predominance of IgG1 which plays a key role in immunity to natural rubella infection. The immune response was generally directed against the rubella antigen within the complexes. We suggest that SPs can act as a platform (depot) for the rubella antigen, enhancing specific immune response. Our results demonstrate that SPs-antigen complexes can be an effective and safe candidate vaccine against rubella.

Citations

Jul 3, 2020·Human Vaccines & Immunotherapeutics·Ekaterina M RyabchevskayaOlga V Karpova
Jun 1, 2019·PloS One·Alexander L KsenofontovOlga V Karpova
Jul 19, 2018·Advances in Virology·Ekaterina DonchenkoOlga Karpova
Jun 27, 2020·Scientific Reports·Ekaterina A EvtushenkoOlga V Karpova
May 21, 2020·Molecular Biology·E M RyabchevskayaO V Karpova
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Svetlana S KurashovaEvgeniy A Tkachenko
Feb 6, 2021·Virology·Christian Isalomboto Nkanga, Nicole F Steinmetz

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