PMID: 8590953Jan 1, 1996Paper

Study of serum 3,5,3'-triiodothyronine sulfate concentration in patients with systemic non-thyroidal illness

European Journal of Endocrinology
F SantiniA Pinchera

Abstract

Sulfation is an important pathway of triiodothyronine (T3) metabolism. Increased serum T3 sulfate (T3S) values have been observed during fetal life and in pathological conditions such as hyperthyroidism and selenium deficiency. Similar variations have also been reported in a small number of patients with systemic non-thyroidal illness, but the underlying mechanisms have not been elucidated. In this study, serum T3S concentrations have been measured by a specific radioimmunoassay in 28 patients with end-stage neoplastic disease (ESND) and in 44 patients with chronic renal failure (CRF); 41 normal subjects served as controls. Both ESND and CRF patients had lower serum total T4 (TT4) and total T3 (TT3) than normal controls, while serum reverse T3 (rT3) was increased significantly in ESND (0.7 +/- 0.5 nmol/l; p < 0.001 vs. controls) but not in CRF (0.3 +/- 0.1 nmol/l). The TT3/rT3 ratio, an index of type I iodothyronine monodeiodinase (type I MD) activity, was reduced significantly in both groups of patients. Serum T4-binding globulin (TBG) was decreased in CRF but not in ESND patients. Serum T3S was significantly higher both in ESND (71 +/- 32 pmol/l) and CRF (100 +/- 24 pmol/l) than in controls (50 +/- 16 pmol/l, p < 0.001). Seru...Continue Reading

Citations

Sep 27, 2005·Journal of the American Society for Mass Spectrometry·Yuntao ZhangGary W Conrad
Jul 20, 1999·Molecular and Cellular Endocrinology·V M DarrasT J Visser
Aug 30, 2000·Schizophrenia Research·A BaumgartnerW Gaebel
Jul 20, 2010·Seminars in Dialysis·Emaad M Abdel-RahmanJean L Holley
Oct 2, 2012·Néphrologie & thérapeutique·Matthieu PonsoyeHassane Izzedine
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Merlin C ThomasGraeme R Russ
Nov 15, 2008·Seminars in Perinatology·Sergio G Golombek
May 31, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Giorgia QuerciFerruccio Santini
Jun 27, 2018·American Journal of Physiology. Endocrinology and Metabolism·Jennifer D DeemGregory J Morton
Apr 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Frank Jan de JongMonique M B Breteler
Feb 13, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ferruccio SantiniAldo Pinchera
Apr 13, 1999·The Journal of Clinical Endocrinology and Metabolism·M H KesterT J Visser

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