Study of serum haptoglobin level and its relation to erythropoietic activity in Beta thalassemia children

Mediterranean Journal of Hematology and Infectious Diseases
Seham M RagabEman A Badr

Abstract

Serum haptoglobin (Hp) is a reliable marker for hemolysis regardless the inflammatory state. We investigated the possible relation between Hp depletion and hemolysis severity, hepatitis C virus (HCV) infection and iron load in β-thalassemia children. Twenty two β-thalassemia major (TM),20 β-thalassemia intermedia (TI) children with 20 age and sex matched healthy controls were involved. Pre-transfusion hemoglobin level was considered. Serum ferritin, Hp and transferrin receptor levels (sTfR) (by ELISA ), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (by colorimetric method) were assayed. Markers of hepatitis C virus (HCV) were done by PCR. The mean Hp levels among the studied groups were as follows; 8.02 ± 0.93 (mg/dl), 8.6 ±0.72 (mg/dl) and 122 ± 18.5(mg/dl) for TM, TI and the controls respectively. Both patient groups had significantly lower Hp level compared to the controls (P<0.0001) with significant lower level in TM compared to TI children ( P= 0.034). Significant inverse correlations were found between serum Hp and sTfR levels ( reflecting the erythropoietic activity) in thalassemia children combined and in each group (TM and TI) as well as among HCV infected children. STfR was the only significant i...Continue Reading

Citations

Aug 29, 2018·Journal of Clinical Pharmacology·Muhammad ZohaibShamshad Zarina
Apr 14, 2018·American Journal of Respiratory Cell and Molecular Biology·Olga RafikovaRuslan Rafikov
Apr 28, 2017·Molecular Medicine Reports·Kamonlak LeecharoenkiatTsukuru Umemura
Sep 4, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Szu-Chin LiYu-Chieh Su
Jun 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rafaela MendonçaNicola Conran
Jul 17, 2020·Clinical and Experimental Pediatrics·Nora SoviraMohammad Sadikin
Mar 3, 2021·Orphanet Journal of Rare Diseases·Nirmani YasaraSachith Mettananda

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
enzyme-linked immunoabsorbent assay
Assay
ELISA
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2022 Meta ULC. All rights reserved