PMID: 28502157Jan 1, 2016Paper

Study of Serum Immunoglobulin Levels and T lymphocyte Subsets in Children with Beta Thalassemia with Iron Overload in Egypt

The Egyptian Journal of Immunology
Adel A HagagEnaam S Abd Elbar

Abstract

Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy. Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload, which in addition to immune abnormalities, are common predisposing factors to infection in patients with thalassemia. The aim was to study serum immunoglobulin levels and T lymphocyte subsets in children with beta- thalassemia in relation to iron overload. This study was conducted on 40 children with beta thalassemia major including 24 males and 16 females with mean age of 9.22 ± 3.9 and 20 healthy children of matched age and sex as a control. All children were subjected to assessment of infection episodes, complete blood picture, Hb electrophoresis, serum iron status, T cell subsets including CD3, CD4 and CD8 using Becton Dickinson FAC Scan flow cytometer and serum immunoglobulin levels including IgM, IgA and IgG by a commercial nephelometry assay using a BN-II device. Serum ferritin and iron were significantly higher but total iron binding capacity was significantly lower in patients than controls (Mean serum ferritin was 3418.23±2950.7 in the studied patients versus 39.48±2.48 in the control group with p valu...Continue Reading

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Endocrine, Metabolic & Immune Disorders Drug Targets
Adel A HagagAmany M Abo El-Enein
Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Mohammad Hadi SadeghianMasoumeh Mahmoudi
© 2022 Meta ULC. All rights reserved