PMID: 19938595Nov 27, 2009Paper

Study of specificity of fungistatic effect of trichothecene mycotoxins

Mikrobiolohichnyĭ zhurnal. = Mikrobiologichny zhurnal
A M ZaĭchenkoE S Tsyganenko

Abstract

In attempt to realize the purposeful search of highly sensitive and highly specific microbial test-cultures the authors studied the ratio between selected before species of yeast to the wide set of different mycotoxins including macrocyclic trichothecenes (T-2 toxin, HT-2 toxin, T-2 triol, T-2 tetraol, NT-1 toxin, NT-2 toxin, fusarenon-X, diacetoxyscirpenol, deoxynivalenol, trichothecin, trichothecolon, neosolaniol, verrucarin A, roridin A, roridin H, aflatoxins, B1, B2, G1 and G2, sterigmatocystin, patulin, fusaric acid, ochratoxin A, zearalenon and their derivatives). It was supposed to define borders of specific sensitivity of test-cultures. The value of minimal inhibiting concentration (MIC) of mycotoxins, which caused fungicide action in respect of the investigated yeast strains, was used as the estimation criterion. Extremely few species with narrow specific sensitivity to individual trichothecenes were found. Strains with group sensitivity to investigated trichothecene mycotoxins (MCTC) were more widely presented. Selectivity in respect of either simple (T-2 toxin), or MCTC (verrucarin A, roridin A, roridin H) is traced for some species. Taxons with mixed selectivity were discovered. Exceptionally high fungistatic activi...Continue Reading

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