Study of testosterone-guided androgen deprivation therapy in management of prostate cancer

The Prostate
Saroj NiraulaIan F Tannock

Abstract

Androgen deprivation therapy (ADT) with luteinizing hormone releasing hormone (LHRH) agonists is an effective initial therapy for men with advanced prostate cancer. LHRH agonists are usually administered indefinitely at a fixed interval. We recruited men with advanced prostate cancer who had been on fixed-schedule injections of an LHRH agonist for ≥1 year and had castrate serum testosterone [<1.75 nmol/l (approx. 50 ng/ml)]. Testosterone levels were measured at 6-week intervals and ADT was withheld until testosterone levels were no longer in the castrate range and then reinstituted. Time to reinstitution of ADT was the primary outcome and was analyzed by the Kaplan-Meier method; Cox regression was used to identify factors predicting delay in reinstitution of treatment. Influence on quality-of-life (QoL) was evaluated by the Expanded Prostate Index Composite (EPIC). Forty-six evaluable men who had received LHRH agonist injections every 12 weeks were recruited. Median time to testosterone recovery (defined as testosterone outside the defined castrate level) after previous injection was >1 year. In univariable analysis, lower baseline testosterone [≤1 vs. >1 nmol/l (approx. 30 ng/dl)] and longer time on ADT (>5 vs. ≤5 years) predi...Continue Reading

References

Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·D A RedelmeierG H Guyatt
Sep 4, 1999·Age and Ageing·S GiampaoliA Menotti
Oct 9, 1999·The European Respiratory Journal·T TroostersM Decramer
Jun 20, 2002·Clinical Endocrinology·Shehzad BasariaAdrian S Dobs
Oct 24, 2003·The New England Journal of Medicine·Jennie T ChangJulie Beitz
Jan 11, 2005·BJU International·Vijay K SangarRosie A Blades
Jul 28, 2005·European Urology·G AusUNKNOWN European Association of Urology
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Dec 23, 2006·Cancer·Leslie S WilsonPeter R Carroll
Nov 21, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Giuseppe ColellaVittorio Fusco
Oct 12, 2010·The Journal of Clinical Endocrinology and Metabolism·William RosnerUNKNOWN Pediatric Endocrine Society
Nov 12, 2010·Journal of the National Cancer Institute·Silke GillessenVahakn B Shahinian
Sep 13, 2011·European Urology·Laurent AzoulaySamy Suissa
Dec 8, 2011·JAMA : the Journal of the American Medical Association·Paul L NguyenToni K Choueiri
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Shabbir M H AlibhaiLawrence Paszat
Dec 30, 2014·The Journal of Urology·Juan MoroteUNKNOWN ANAMET Investigators Group

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Citations

Jan 28, 2016·Nature Reviews. Urology·Tsutomu Nishiyama, Tatsuhiko Hoshii

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