Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy

Biogerontology
L ScolaC Caruso

Abstract

Immune response in elderly is characterised by a progressive loss of the ability to cope environmental stressors with a characteristic remodelling of cytokine network. One of the data constantly reported in literature is the decrease of IL-2 production. An IL-2 central role in the reconstitution of T cell function in vitro is largely documented. Studies on a T-->G polymorphism at -330 nt of IL-2 gene promoter region have demonstrated that T lymphocytes from 330GG homozygous subjects are able to produce in vitro higher amount of IL-2, than -330TG heterozygous or -330TT homozygous subjects. As a genetic background conditioning the maintaining of an efficient immune response would exert positive effects on healthy ageing, we have typed for 330T/G IL-2 single nucleotide polymorphism (SNP), 168 centenarians and 214 control subjects matched for age and ancestry from Centre and South Italy to check the 330GG genotype association to longevity. The statistical analysis doesn't show a significant difference of genotypic and allelic frequencies at -330 IL-2 T/G SNP among centenarians and controls. Comparing the two cohorts of subjects by extended Mantel Haenszel procedure a marginally significant trend for an increased -330TT genotype fre...Continue Reading

References

Jan 1, 1995·Immunology Today·C FranceschiA Cossarizza
Jan 1, 1996·Immunologic Research·C CarusoA Salerno
Apr 1, 1997·Cytometry·A CossarizzaC Franceschi
Feb 9, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S JohnA H Hajeer
Sep 21, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M P ReynardC V Navarrete
Nov 9, 2000·Immunology Today·A Globerson, R B Effros
Feb 24, 2001·Genes and Immunity·J BidwellS D'Alfonso
Jun 8, 2001·Genes and Immunity·J BidwellS D'Alfonso
Jan 5, 2002·Experimental Gerontology·Nadine DouziechTamàs Fulop
Feb 1, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M Uboldi Uboldi de CapeiE S Curtoni
Mar 14, 2003·Mechanisms of Ageing and Development·Owen A RossI Maeve Rea
Feb 21, 2004·Journal of Neuroimmunology·Fuencisla MatesanzAntonio Alcina
Jan 19, 2005·Science·Calogero CarusoClaudio Franceschi
Apr 13, 2005·Atherosclerosis·Mitchell S V ElkindRalph L Sacco
May 21, 2005·Immunity & Ageing : I & a·Federico LicastroCalogero Caruso
Jun 21, 2005·Journal of the American College of Cardiology·Heiko MetheElazer R Edelman

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Citations

Aug 19, 2011·Human Biology·Tommaso Iannitti, Beniamino Palmieri
Dec 15, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Paola Lucia MinciulloGiorgio Basile
Nov 23, 2006·Mechanisms of Ageing and Development·Claudio FranceschiStefano Salvioli
Apr 27, 2007·Annals of the New York Academy of Sciences·Maria Paola GrimaldiGiuseppina Candore
Jun 4, 2010·International Journal of Immunogenetics·O F Khabour, J M Barnawi
Apr 11, 2008·Physiology·Anis LarbiGraham Pawelec
Dec 21, 2011·Journal of Immunoassay & Immunochemistry·Marisa PalmeriDomenico Lio
Jun 1, 2021·Frontiers in Immunology·Miguel Ángel Palacios-PedreroGiulietta Saletti

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