Study of the chain microstructure effects on the resulting thermal properties of poly(L-lactide)/poly(N-isopropylacrylamide) biomedical materials

Materials Science & Engineering. C, Materials for Biological Applications
E LizundiaL M León Isidro

Abstract

The development of thermally-sensitive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible/biodegradable poly(L-lactide) (PLLA) blends offers us an efficient strategy in order to obtain materials with improved functional properties to be used in the emerging field of biomedicine. In this sense, thermal properties of PLLA and PNIPAAm have been investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and wide angle X-ray diffraction (WAXD) were conducted to shed more light on the obtained results. For a better understanding of PLLA/PNIPAAm system, both low and high molecular weight PLLA and PNIPAAm have been synthesized by ring opening polymerization and aqueous redox polymerization respectively. Obtained results are interpreted from the viewpoint of chain microstructure of each homopolymer and the ratio between two constituent materials. DSC, SEM and WAXD results show a phase separation over the entire composition range irrespectively of the molecular weight of both homopolymers. Additionally, it was found a nucleating agent behavior of low molecular weight PNIPAAm, while high molecular weight PNIPAAm hinde...Continue Reading

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Citations

Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Renyuan SongChaoli Wang
Jan 9, 2016·Journal of Biomedical Materials Research. Part a·Zhengqiu LiMichasel Martyn
Aug 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiajie LinYulin Li
Oct 16, 2021·Journal of Biomedical Materials Research. Part a·Zhengqiu LiBaoshu Chen

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