Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A ProsperiniMaría José Ruiz

Abstract

Beauvericin (BEA) is a cyclohexadepsipeptide mycotoxin which has insecticidal properties and produces cytotoxic effects in mammalian cells. Fusaproliferin (FUS) is a mycotoxin that has toxic activity against brine shrimp, insect cells, and teratogenic effects on chicken embryos. The aim of this study was to determine the cytotoxicity of BEA and FUS in human epithelial colorectal adenocarcinoma HT-29 and Caco-2 cells, the transepithelial transport and the bioavailability using Caco-2 cells as a simulated in vitro gastrointestinal model of the human intestinal epithelium. The inhibitory concentration (IC(50)) evidenced by BEA in the Caco-2 cells was 24.6 and 12.7 μM at 24 and 48 h exposure, respectively, whereas the IC(50) values evidenced in HT-29 cells were 15.0 and 9.7 μM, respectively. FUS was cytotoxic, but no IC(50) data were observed in the range of concentration tested. BEA bioavailability was variable from 50.1% to 54.3%, whereas FUS presented a bioavailability variable from 80.2% to 83.2%. Results obtained demonstrated a potential risk for human health.

References

Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppina AvantaggiatoAngelo Visconti
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppina AvantaggiatoAngelo Visconti
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Carolien H M VersantvoortAdriënne J A M Sips
Aug 12, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bernadette VidemannSylvaine Lecoeur
Oct 31, 2008·Talanta·P AmbrosinoA Ritieni
Jul 15, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E FerrerM J Ruiz
Jul 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G MecaJ Mañes
Nov 26, 2009·Nutrition Research·Elisabet Fernández-GarcíaAntonio Pérez-Gálvez
Mar 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppe MecaJordi Mañes
Mar 1, 2011·Toxicon : Official Journal of the International Society on Toxinology·Diana C TanMartin J Barbetti
Jun 7, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G MecaM J Ruiz
Jul 30, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María-José RuizGuillermina Font
Nov 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppe MecaMaría-José Ruiz
Jun 1, 2006·Mycotoxin Research·J F Leslie, B A Summerell

❮ Previous
Next ❯

Citations

Mar 11, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Lien TaevernierBart De Spiegeleer
Aug 17, 2014·Journal of Pharmaceutical and Biomedical Analysis·Lien TaevernierBart De Spiegeleer
Feb 15, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L EscriváL Manyes
Mar 12, 2015·Journal of Exposure Science & Environmental Epidemiology·Lien TaevernierBart De Spiegeleer
Jul 30, 2014·Journal of Toxicology and Environmental Health. Part a·Ricardo AssunçãoPaula Alvito
Dec 3, 2014·Toxicon : Official Journal of the International Society on Toxinology·C ChiesiM J Ruiz
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Davide FerrigoRoberto Causin
Jul 31, 2016·Reproductive Toxicology·Eric J SchoeversBernard A J Roelen
Sep 8, 2016·Journal of Agricultural and Food Chemistry·Christiane Gruber-DorningerFranz Berthiller
Sep 12, 2018·Drug and Chemical Toxicology·Sevcan MamurDeniz Yüzbaşıoğlu
Jun 20, 2018·Toxins·Alessia BerteroFrancesca Caloni
Nov 4, 2020·Toxins·Alessia BerteroFrancesca Caloni
May 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Domenico MontesanoCristina Juan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.