Abstract
It is recently reported that galanin plays a role in memory decline that is the primary behavioral symptom of Alzheimer's disease. The aim of the present study was to study the impact of administration of two antidiabetic drugs that might inhibit galanin, namely glibenclamide and pioglitazone, on the behavioral, and neurochemical changes in Alzheimer's disease--induced in rats by intracerebroventricular (i.c.v.) injection of beta amyloid (Abeta). The present study was conducted on 60 male Wistar rats that were divided into 6 groups: group I (control group) which received i.c.v. scrambled peptide, group II (i.c.v.-Abeta group) which received i.c.v.-Abeta, groups III and IV that received, respectively, glibenclamide and pioglitazone daily orally for 3 weeks following scrambled peptide administration as well as groups V and VI that received, respectively, glibenclamide and pioglitazone daily orally for 3 weeks following Abeta administration. i.c.v.-Abeta resulted in significant behavioral alterations suggesting Alzheimer's disease, where there was significant impairment in spatial cognition, evaluated by Morris water maze task, and in learning and memory performance, assessed using passive-avoidance learning task. i.c.v.-Abeta als...Continue Reading
References
Apr 1, 1992·Journal of Neuroscience Methods·G F Jirikowski
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J de WeilleM Lazdunski
Aug 1, 1971·Physiology & Behavior·D Winer
May 1, 1984·Journal of Neuroscience Methods·R Morris
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S ShearmanL L Iversen
Jul 1, 1993·Neurobiology of Aging·M J West
Apr 1, 1997·Neuroendocrinology·C TangS F Leibowitz
Feb 4, 1998·Brain Research·J Wang, K L Leibowitz
Jun 24, 1999·Journal of Neuroscience Methods·A K MudherJ R Greene
Dec 28, 1999·European Journal of Pharmacology·S K Mishra, P I Aaronson
Feb 26, 2000·Trends in Pharmacological Sciences·T A BranchekM W Walker
Aug 15, 2002·Learning & Memory·Jefferson W KinneyJacqueline N Crawley
Dec 11, 2002·Circulation·Tetsuya ShiomiAkira Takeshita
Apr 5, 2003·Drug News & Perspectives·Peter J. McLaughlin, John K. Robinson
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Maria E Vrontakis
Aug 6, 2004·Nature·Mark P Mattson
Apr 7, 2005·Genes, Brain, and Behavior·A Stéphan, A G Phillips
Nov 25, 2005·Pharmacology & Therapeutics·Liang Guo, Reza Tabrizchi
Feb 8, 2007·Drugs of Today·P RevillJ R Prous
Jul 3, 2007·Pharmacology & Therapeutics·Roland LangBarbara Kofler
Sep 22, 2007·Behavioural Brain Research·Yann SenechalKumlesh K Dev
Feb 22, 2008·Current Alzheimer Research·Olaf Schulte-HerbrüggenRainer Hellweg
Mar 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·A S SlingerlandM Hadders-Algra
Apr 4, 2008·Neuroscience Letters·T Jarred EwertBeth A Habecker
May 27, 2008·Cellular and Molecular Life Sciences : CMLS·J N Crawley
May 27, 2008·Cellular and Molecular Life Sciences : CMLS·K MitsukawaT Bartfai
Jul 16, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gary LandrethMichael Heneka
Oct 16, 2008·Current Alzheimer Research·Karen F NeumannRicardo B Maccioni
Nov 22, 2008·Stroke; a Journal of Cerebral Circulation·J Marc SimardVolodymyr Gerzanich
Jun 18, 2009·Neurobiology of Learning and Memory·Jefferson W KinneyTamas Bartfai
Jul 29, 2009·Hypertension·Kana TsukudaMasatsugu Horiuchi
Citations
Oct 22, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·R O DomínguezJ A Serra
Aug 15, 2014·Frontiers in Aging Neuroscience·Wei Qiao Qiu, Haihao Zhu
Feb 23, 2017·Journal of Alzheimer's Disease : JAD·Karla Salgado-PugaFernando Peña-Ortega
Aug 25, 2017·Journal of the International Neuropsychological Society : JINS·Gianna CocchiniSergio Della Sala
Nov 28, 2014·Pharmacological Reviews·Roland LangBarbara Kofler
Aug 28, 2020·The FEBS Journal·Jahnavi SureshNicholas S Tolwinski
Jun 30, 2019·International Journal of Molecular Sciences·Rui ZhengGuo-Li Song
Oct 13, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S AlfordC S Mantzoros
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Feb 21, 2021·Ageing Research Reviews·Benjamin KioussisAndrea B Maier
Jun 26, 2021·World Journal of Diabetes·Milagros RojasValmore Bermúdez
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa
Jul 30, 2020·European Journal of Pharmacology·Yeon-Joo JuJong Kil Lee