Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats

European Journal of Pharmacology
Azza Baraka, Samar ElGhotny

Abstract

It is recently reported that galanin plays a role in memory decline that is the primary behavioral symptom of Alzheimer's disease. The aim of the present study was to study the impact of administration of two antidiabetic drugs that might inhibit galanin, namely glibenclamide and pioglitazone, on the behavioral, and neurochemical changes in Alzheimer's disease--induced in rats by intracerebroventricular (i.c.v.) injection of beta amyloid (Abeta). The present study was conducted on 60 male Wistar rats that were divided into 6 groups: group I (control group) which received i.c.v. scrambled peptide, group II (i.c.v.-Abeta group) which received i.c.v.-Abeta, groups III and IV that received, respectively, glibenclamide and pioglitazone daily orally for 3 weeks following scrambled peptide administration as well as groups V and VI that received, respectively, glibenclamide and pioglitazone daily orally for 3 weeks following Abeta administration. i.c.v.-Abeta resulted in significant behavioral alterations suggesting Alzheimer's disease, where there was significant impairment in spatial cognition, evaluated by Morris water maze task, and in learning and memory performance, assessed using passive-avoidance learning task. i.c.v.-Abeta als...Continue Reading

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Citations

Oct 22, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·R O DomínguezJ A Serra
Aug 15, 2014·Frontiers in Aging Neuroscience·Wei Qiao Qiu, Haihao Zhu
Aug 25, 2017·Journal of the International Neuropsychological Society : JINS·Gianna CocchiniSergio Della Sala
Oct 13, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S AlfordC S Mantzoros
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Jun 26, 2021·World Journal of Diabetes·Milagros RojasValmore Bermúdez
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa
Jul 30, 2020·European Journal of Pharmacology·Yeon-Joo JuJong Kil Lee

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