PMID: 19918664Nov 18, 2009Paper

Study of the effect of streptokinase and allopurinol in island skin flaps submitted to prolonged ischemia: experimental study in rats

Revista da Associação Médica Brasileira
Tatiana de MouraMarcus Castro Ferreira

Abstract

To establish a relation between the survival rate of island skin flaps submitted to prolonged ischemia and the effect of streptokinase and allopurinol administered after the ischemic period. A total of 48 male Winstar rats, each weighing between 300 and 350 grams,were separated into four groups of twelve as follows: control, allopurinol, streptokinase and association of allopurinol and streptokinase, were submitted to an epigastric island flap dissection followed by epigastric vessel bundle clamping. Flaps remained this way for 8 hours in normothermic mixed ischemia. After the ischemic period, clamps were removed and each rat received the therapeutical scheme proposed for the group by intravenous injections. Flap survival analysis was performed on the seventh post operative day. Variance and descriptive analyses (as a percentage of the necrotic area) as well as Dunnett-T3 multiple comparisons among the 4 groups and median tests were carried out. Rats in the control group presented an average of 79.88% of necrosis in the flap total area; those which received allopurinol presented an average of 64.05% of necrosis whereas the group which received streptokinase showed an average of 55.52% of necrosis. With the association of both d...Continue Reading

Citations

Oct 12, 2017·Revista do Colégio Brasileiro de Cirurgiões·Stephanie Luzia da Costa PedrettiTarcizo Afonso Nunes

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