PMID: 7952870Aug 1, 1994Paper

Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis

British Journal of Pharmacology
M I PellonM Sánchez Crespo

Abstract

1. The effector mechanism of intestinal necrosis in rat anaphylaxis was studied following several complementary approaches: (i) the use of monoclonal antibodies (mAb) belonging to different classes (IgG1, IgG2b and IgE anti-DNP), (ii) the assay of mediators, and (iii) the use of pharmacological tools. 2. Lethality and haemorrhagic necrosis of the small intestine were observed in IgE-sensitized rats, whereas IgG mAb produced milder physiological disturbances. 3. Inhibition of leukotriene biosynthesis reduced the drop of systemic blood pressure (BP) and the extent of protein-rich plasma exudation but it did not influence the haemorrhagic component of intestinal necrosis. 4. The antihistamine, pyrilamine, partially diminished the haemorrhagic component of the intestinal necrosis. 5. The involvement of mediators related to platelet-activating factor (PAF) was studied by examining the pharmacological effects of these autacoids and of PAF-receptor antagonists (PCA4248, UR12460 and BB823). PAF induced intestinal lesions similar to those observed in IgE-sensitized rats and PAF-receptor antagonists markedly decreased haemorrhage in IgE-sensitized rats. 6. PAF levels were transiently increased after dinitrophenol (DNP)- bovine serum albu...Continue Reading

References

Jan 1, 1992·British Journal of Pharmacology·S Fernández-GallardoM Sánchez Crespo
Sep 1, 1991·The Journal of Clinical Investigation·Y ZhangB A Jakschik
Aug 13, 1991·Biochimica Et Biophysica Acta·K L ClayG S Worthen
Jan 1, 1991·Annual Review of Immunology·J V Ravetch, J P Kinet
Sep 1, 1989·Circulation Research·U del BalzoR Levi
Jun 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·M T LinL T Ho
Jun 1, 1988·The Journal of Experimental Medicine·A Waage, T Espevik
May 1, 1988·The Journal of Clinical Investigation·X M Sun, W Hsueh
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L Rothstein, H Schreiber
Oct 24, 1986·Science·K J TraceyJ D Albert
Jan 1, 1993·Gastroenterology·C M HogaboamJ L Wallace
Aug 6, 1958·The Journal of Physiology·R K SANYAL, G B WEST
Oct 1, 1961·The Journal of Pathology and Bacteriology·B F FELLD P CUTHBERTSON
Jul 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·E van KAMPEN, W G ZIJLSTRA

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Citations

Dec 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhili XuAndrew P Byrnes
Nov 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R RibeiroE V Tibiriçá
May 20, 2015·Case Reports in Critical Care·Adeleke AdesinaRebecca Jeanmonod
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M CollinsG D Jackson
Mar 24, 2007·Internal Medicine·Toshihiro ShiraiKingo Chida
Feb 7, 2002·Cardiovascular Drug Reviews·E Tibiriçá

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.