Study of the effects of nesfatin-1 on gastric function in obese rats

World Journal of Gastroenterology : WJG
Guo-Tao YangAi-Qin Dong

Abstract

To investigate the effects of nesfatin-1 on gastric function in obese rats. The obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of H+/K+-ATPase was measured using RT-PCR and western blot to preliminarily explore the mechanism of gastric acid secretion changes. Body weight, body length, and Lee's index of the rats significantly increased in the high-fat diet-induced obese rat model. Two hours after lateral intracerebroventricular injection of nesfatin-1, the gastric emptying rate and gastric acid secretory capacity of rats decreased. Four hours after injection, both were restored to normal levels. In addition, the expression of H+/K+-ATPase decreased and moved in line with changes in gastric acid secretory capacity. This in vivo experiment revealed that intracerebroventricular injection of nesfatin-1, rather than intravenous injection, could suppress gastric function in obese rats. Moreover, its effect on the gastric emptying and gastric acid secretory capacity of rats is dose-dependent within a certain period of time. T...Continue Reading

References

Jan 21, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AnthoniC F Krieglstein
Oct 13, 2006·Nature·Shinsuke Oh-IMasatomo Mori
Oct 24, 2007·Peptides·Weihong PanAbba J Kastin
Mar 30, 2013·Current Pharmaceutical Design·Haneesha Mohan, Suraj Unniappan
Mar 30, 2013·Current Pharmaceutical Design·Masanori Nakata, Toshihiko Yada
Mar 30, 2013·Current Pharmaceutical Design·Ziru LiWeizhen Zhang
Mar 30, 2013·Current Pharmaceutical Design·Gina L C Yosten, Willis K Samson
Mar 30, 2013·Current Pharmaceutical Design·Andreas Stengel, Yvette Taché
Apr 6, 2013·PloS One·Szilvia VasZsuzsanna E Tóth
Apr 16, 2013·Biochemical and Biophysical Research Communications·Udval SedbazarToshihiko Yada
Jun 27, 2013·World Journal of Gastroenterology : WJG·Fang-Yuan JiaLin Lin
Sep 26, 2013·Endocrinology·Sandra Feijóo-BandínFrancisca Lago
Jan 8, 2015·Digestive Diseases and Sciences·Akira WatanabeHiroyuki Kuwano
Nov 3, 2015·Endocrine Journal·Xun CaoLi-Hong Zhou
Nov 26, 2015·Biotechnology and Applied Biochemistry·Chunlan XiaoJing Zhang
Jan 26, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ayelén M BlancoSuraj Unniappan
Aug 18, 2016·Frontiers in Physiology·Victoria L Wyckelsma, Michael J McKenna
Aug 20, 2016·Physiological Research·S AlgulO Ozcelik
Aug 27, 2016·Pflügers Archiv : European journal of physiology·Christine WalterGilles Crambert
Sep 3, 2016·Current Opinion in Pharmacology·Philip Prinz, Andreas Stengel
Sep 3, 2016·Current Opinion in Pharmacology·Philip Prinz, Andreas Stengel
Sep 7, 2016·Frontiers in Veterinary Science·Karen M LuchterhandMarcia I Endres
Sep 9, 2016·Journal of Occupational and Environmental Medicine·Xuguang Grant TaoEdward J Bernacki
Sep 13, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yan GuoTong Li
Sep 14, 2016·BMC Complementary and Alternative Medicine·Ji-Hye LeeJin Yeul Ma
Sep 14, 2016·Pediatrics·Sarah C Armstrong, Asheley Cockrell Skinner
Sep 14, 2016·PloS One·Enguerran MaciaPriscilla Duboz
Sep 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kelly E RuhstallerCeleste P Durnwald

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Citations

Nov 1, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Juan Ignacio BertucciLuis Fabián Canosa
Jan 22, 2019·Current Protein & Peptide Science·Eglantina IdrizajMaria Caterina Baccari
Mar 31, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mehmet Bülbül, R Alberto Travagli
Oct 12, 2018·Journal of the Endocrine Society·Martha A Schalla, Andreas Stengel
Mar 20, 2021·Diabetology & Metabolic Syndrome·Mariana de Moura E DiasFermín Ignacio Milagro
Apr 3, 2021·Journal of Neurogastroenterology and Motility·Zarife N Özdemir-KumralBerrak Ç Yeğen
Sep 25, 2021·BMC Gastroenterology·Yuchi ZhangFenggang Ren

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

SPSS Statistics

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