Study of the efficacy and safety of switching from risperidone to paliperidone in elderly patients with schizophrenia

Psychiatry and Clinical Neurosciences
Hidenobu SuzukiKatsunaka Mikami

Abstract

We investigated the clinical efficacy and safety of switching to paliperidone (PAL) in elderly schizophrenia patients receiving risperidone. The subjects were 27 inpatients who had been diagnosed with schizophrenia according to the DSM-IV. The patient's clinical symptoms were assessed using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Severity of Illness Scale, and their safety was assessed using the Drug-induced Extrapyramidal Symptoms Scale, bodyweight, body mass index, and laboratory tests. We also investigated patient satisfaction using the Drug Attitude Inventory, a subjective outcome measure. No significant differences in clinical symptom improvement efficacy were seen between the PAL-switching group and the control group. The mean changes from baseline on the Drug-induced Extrapyramidal Symptoms Scale total score, Drug Attitude Inventory score, and prolactin level were significantly greater in the PAL-switching group than in the control group. Furthermore, patients with PAL needed less biperiden, even though they had similar risperidone-equivalent daily dosages to the control group. The results of this study suggest that switching elderly patients from risperidone to PAL may result in super...Continue Reading

References

Sep 25, 2015·Biomedical Chromatography : BMC·Robert SkibińskiTadeusz Inglot
Jan 8, 2019·New Directions for Child and Adolescent Development·Bo WangJoyce Tang Boyland

Citations

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 4, 1996·The New England Journal of Medicine·J M Kane
Jan 1, 1997·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A G AwadR J Heslegrave
Jun 16, 1999·European Archives of Psychiatry and Clinical Neuroscience·T OhmoriT Koyama
Jul 29, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dan W Haupt
Aug 29, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·John W Newcomer, Dan W Haupt
Aug 2, 2007·Molecular Psychiatry·J A Gray, B L Roth
Jan 1, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Andreas TzimosMariëlle Eerdekens
Jan 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc VermeirAdriaan Cleton
May 26, 2010·International Journal of Clinical Pharmacology and Therapeutics·M P JonesK Trakas

Related Concepts

PRL
Antipsychotic Effect
Laboratory Procedures
Schizophrenia
Paliperidone
Extrapyramidal Sign
Body Mass Index Procedure
Biperiden
Isoxazoles
Prolactin Measurement

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