Study of the efficacy and safety of switching from risperidone to paliperidone in elderly patients with schizophrenia

Psychiatry and Clinical Neurosciences
Hidenobu SuzukiKatsunaka Mikami


We investigated the clinical efficacy and safety of switching to paliperidone (PAL) in elderly schizophrenia patients receiving risperidone. The subjects were 27 inpatients who had been diagnosed with schizophrenia according to the DSM-IV. The patient's clinical symptoms were assessed using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Severity of Illness Scale, and their safety was assessed using the Drug-induced Extrapyramidal Symptoms Scale, bodyweight, body mass index, and laboratory tests. We also investigated patient satisfaction using the Drug Attitude Inventory, a subjective outcome measure. No significant differences in clinical symptom improvement efficacy were seen between the PAL-switching group and the control group. The mean changes from baseline on the Drug-induced Extrapyramidal Symptoms Scale total score, Drug Attitude Inventory score, and prolactin level were significantly greater in the PAL-switching group than in the control group. Furthermore, patients with PAL needed less biperiden, even though they had similar risperidone-equivalent daily dosages to the control group. The results of this study suggest that switching elderly patients from risperidone to PAL may result in super...Continue Reading


Sep 25, 2015·Biomedical Chromatography : BMC·Robert SkibińskiTadeusz Inglot
Jan 8, 2019·New Directions for Child and Adolescent Development·Bo WangJoyce Tang Boyland


Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 4, 1996·The New England Journal of Medicine·J M Kane
Jan 1, 1997·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A G AwadR J Heslegrave
Jun 16, 1999·European Archives of Psychiatry and Clinical Neuroscience·T OhmoriT Koyama
Jul 29, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dan W Haupt
Aug 29, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·John W Newcomer, Dan W Haupt
Aug 2, 2007·Molecular Psychiatry·J A Gray, B L Roth
Jan 1, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Andreas TzimosMariëlle Eerdekens
Jan 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc VermeirAdriaan Cleton
May 26, 2010·International Journal of Clinical Pharmacology and Therapeutics·M P JonesK Trakas

Related Concepts

Antipsychotic Effect
Laboratory Procedures
Extrapyramidal Sign
Body Mass Index Procedure
Prolactin Measurement

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Christian DolderZachariah Deyo
© 2020 Meta ULC. All rights reserved