PMID: 9532242Apr 9, 1998Paper

Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
C A SouzaF J Paumgartten

Abstract

The crude latex of Crown-of-Thorns (Euphorbia milii var. hislopii) is a potent plant molluscicide and a promising alternative to the synthetic molluscicides used in schistosomiasis control. The present study was undertaken to investigate the embryofeto-toxic potential of E. milii latex. The study is part of a comprehensive safety evaluation of this plant molluscicide. Lyophilized latex (0, 125, 250 and 500 mg/kg body weight) in corn oil was given by gavage to Wistar rats (N = 100) from days 6 to 15 of pregnancy and cesarean sections were performed on day 21 of pregnancy. The numbers of implantation sites, living and dead fetuses, resorptions and corpora lutea were recorded. Fetuses were weighed, examined for external malformations, and fixed for visceral examination, or cleared and stained with Alizarin red S for skeleton evaluation. A reduction of body weight minus uterine weight at term indicated that E. milii latex was maternally toxic over the dose range tested. No latex-induced embryolethality was noted at the lowest dose (125 mg/kg) but the resorption rate was markedly increased at 250 mg/kg (62.5%) and 500 mg/kg (93.4%). A higher frequency of fetuses showing signs of delayed ossification (control: 17.4%; 125 mg/kg: 27.4%...Continue Reading

References

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Citations

Jan 1, 2004·Environmental Toxicology and Pharmacology·Sunil Kumar SinghAjay Singh
May 27, 2003·Toxicology Letters·Eliane DallegraveAugusto Langeloh
Oct 29, 2003·Toxicology Letters·I F DelgadoF J R Paumgartten
Dec 30, 2009·Journal of Ethnopharmacology·Nelson Fernando Quallio MarquesPaulo Roberto Dalsenter
Mar 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Fernanda B MelloJoão R B Mello
Jul 15, 2006·Phytochemistry·Subhash C YadavM V Jagannadham
Jul 25, 2000·Ecotoxicology and Environmental Safety·E C Oliveira-Filho, F J Paumgartten
Oct 17, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Cynthia de Paula-AndradeEdward Oliveira
Nov 9, 2018·Veterinary Sciences·Ronaldo de Carvalho Augusto, Clélia Christina Mello Silva
Sep 6, 2011·Biotechnology Advances·Nuria González-RábadeMaría Del Carmen Oliver-Salvador

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