Study of the force dynamics at the capsular interface related to ciliary body stimulation in a primate model

Journal of Refractive Surgery
Jorge L Alió, Joshua Ben-Nun

Abstract

To study the mechanical dynamics between the zonuli-capsular complex and an accommodating intraocular lens mechanics simulator using pharmacological stimulation of the ciliary body in a primate eye. Following phacoemulsification removal of the lens, force/movement gauges simulating the accommodating intraocular lens mechanics were implanted in 8 primate eyes (4 positioned in-the-bag and 4 on-the-bag). The gauge readings were taken under full effect of pilocarpine 4% or atropine 1% starting 6 weeks after surgery and following 3-month intervals for 30 months. An average movement of 390 µm for on-the-bag gauges and 145 µm for in-the-bag gauges was documented at 3 months postoperatively. The mechanical compliance of in-the-bag gauges rapidly deteriorated with capsular fibrosis developing inside the gauge and the capsular bag shrinking around it. On-the-bag gauges remained functional but the initial compliance was compromised over time by the pressure build up caused by the fibrotic capsular bag. Following phacoemulsification, capsular fibrosis causes disappearance of the mechanical forces detected by an in-the-bag gauge. An on-the-bag gauge detects active forces at the sulcus lasting at least 5 years, although the contracting capsu...Continue Reading

References

Aug 1, 1977·The Journal of Physiology·R F Fisher
Oct 26, 2005·Journal of Cataract and Refractive Surgery·Joshua Ben-Nun, Jorge L Alió
Nov 4, 2006·Journal of Cataract and Refractive Surgery·Susan A StrenkSuqin Guo
Nov 14, 2007·Journal of Vision·A Belaidi, B K Pierscionek

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Citations

Feb 2, 2016·American Journal of Ophthalmology·Jorge L AlioMichiel Rombach
Jan 16, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Mary Ann CroftPaul L Kaufman
Sep 23, 2016·Current Opinion in Ophthalmology·Jay S PeposeMujtaba A Qazi
Dec 18, 2018·Journal of Current Ophthalmology·Jasmin Zvorničanin, Edita Zvorničanin
Jul 5, 2017·Eye and Vision·Jorge L AlióAlfredo Vega-Estrada
Jul 28, 2020·Eye·Marcus AngJorge L Alió

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