PMID: 7523939Nov 1, 1994Paper

Study of the genotoxic activity of five chlorinated propanones using the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test

Mutation Research
F Le CurieuxF Erb

Abstract

Three short-term assays (the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test) were carried out to evaluate the genotoxicity of five chlorinated propanones identified in several chlorinated waters (monochloropropanone, 1,1-dichloropropanone, 1,3-dichloropropanone, 1,1,1-trichloropropanone and 1,1,3-trichloropropanone). In the SOS chromotest, all the compounds except monochloropropanone were found to induce primary DNA damage in Escherichia coli. With the fluctuation test, all five chloropropanones showed mutagenic activity on Salmonella typhimurium strain TA100. The newt micronucleus assay detected a clastogenic effect on the peripheral blood erythrocytes of Pleurodeles waltl larvae only for 1,3-dichloropropanone and 1,1,3-trichloropropanone. Moreover, two structure-activity relationships are noticeable: (1) chloropropanones with chlorine substituents on both carbon positions (1,3-DCP and 1,1,3-TCP) are by far more genotoxic than chloropropanones substituted only on one carbon position (1,1-DCP and 1,1,1-TCP); (2) the increase of the number of chlorine substituents decreases the mutagenic activity (fluctuation test) of the chlorinated propanones studied.

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Citations

May 30, 2009·Environmental Science and Pollution Research International·Jan Bernd Barhorst, Roland Kubiak
Jan 8, 1999·Mutation Research·B S Kim, B H Margolin
Dec 1, 1995·Mutation Research·S GillerD Marzin
Sep 26, 2014·Chemical Research in Toxicology·Suramya WaidyanathaTimothy R Fennell
May 13, 2004·Journal of Exposure Analysis and Environmental Epidemiology·Xu Xu, Clifford P Weisel
Nov 7, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven M BryceStephen D Dertinger
Mar 16, 2018·The Journal of Toxicological Sciences·Yu HaranosonoHideyuki Sakaki
Mar 13, 2003·Environmental Science & Technology·Xu Xu, Clifford P Weisel

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