Study of the in vitro effect on glomerular albumin permselectivity of serum before and after renal transplantation in focal segmental glomerulosclerosis

Transplantation
Yann GodfrinJ P Soulillou

Abstract

The selective proteinuria observed in patients with focal segmental glomerulosclerosis (FSGS) suggests an abnormal loss of fixed anionic charges on the glomerular capillary wall. In this article, we have studied the putative presence of such factor(s) by using a new in vitro assay to assess glomerular permselectivity by measuring glomerular volume variation (GVV) in isolated glomeruli after hypotonic stress. We randomly tested the serum GVV activity of 10 healthy donors and 143 patients before transplantation. Of the patients, 80 had FSGS, 26 membranous glomerulonephritis, 19 polycystic kidney disease, and 18 malformative uropathies. Moreover, we tested the pre- and posttransplantation serum of 14 patients with recurrence and 14 without recurrence. Serum GVV was significantly higher in patients with FSGS than in those with the other end-stage renal diseases studied (P<0.01) or in healthy donors (P<0.01). However, a wide distribution of serum GVV activity in patients with and without FSGS was observed. Statistically, pregraft GVV values were not predictive of the recurrence of FSGS after transplantation. Moreover, we observed a significant decrease in serum GVV activity after transplantation in patients without recurrence (P<0.0...Continue Reading

References

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Citations

Nov 13, 2002·Kidney International·Stephen M Korbet
Apr 22, 2003·Seminars in Nephrology·Virginia J SavinMukut Sharma
Nov 10, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Caroline Hervé, Jacques Dantal
Jun 18, 2004·Kidney International·Maria del Carmen Avila-CasadoJaime Herrera-Acosta
Apr 8, 2009·The Journal of Clinical Investigation·Lihua BaoRichard J Quigg
Feb 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·William A GolgertSundaram Hariharan
Nov 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rutger J MaasJack F Wetzels
Oct 29, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samir M Parikh
Aug 25, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Virginia J Savin, Mukut Sharma
Jun 13, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sarah BruneauJacques Dantal
May 5, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sarah Bruneau, Jacques Dantal
Apr 21, 2007·Transplantation Proceedings·J T Crosson
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H I CheongY Choi
Jan 8, 2004·Experimental Biology and Medicine·Mukut SharmaVirginia J Savin
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Michele CarraroGian Marco Ghiggeri
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Daniel CattranVirginia J Savin
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Richard J Glassock
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Steven James Chadban
Sep 3, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J S KimJ S Zaltzman
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R Dall'AmicoF Ginevri

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