Study of the Interactions Between Bacteriophage phiIPLA-RODI and Four Chemical Disinfectants for the Elimination of Staphylococcus aureus Contamination

Viruses
Seila AgúnPilar García

Abstract

Bacteriophages are currently considered as a promising alternative to antibiotics and disinfectants. However, the use of phages in different clinical and industrial settings will involve their exposure to other disinfectants. As a result, the outcome of the phage treatment will depend on two aspects derived from such interactions. On the one hand, the susceptibility of the phage to disinfectants at the concentrations used for disinfection and at lower residual concentrations needs to be determined. Additionally, the existence of synergistic or antagonistic interactions between phages and disinfectants would also affect the potential success of phage biocontrol applications. Here, we tested these effects for the antistaphylococcal phage phiIPLA-RODI by using four different disinfectants: benzalkonium chloride, triclosan, chlorhexidine and hydrogen peroxide. Our results highlight the differences between disinfectants regarding their effect on phage survival and antimicrobial properties. For instance, our data suggests that, out of the four disinfectants used, benzalkonium chloride would be the most adequate to use in settings where phages are to be applied. Nonetheless, this preliminary analysis grants the need for further studie...Continue Reading

References

Feb 1, 1977·Antimicrobial Agents and Chemotherapy·P F DoughertyT R Matthews
Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Mar 2, 2006·The Journal of Antimicrobial Chemotherapy·Sally A RobertsArthur J Morris
Aug 31, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F DrobniewskiUNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobi
Feb 16, 2012·Bacteriophage·Stephen T AbedonElizabeth Martin Kutter
Oct 2, 2012·Applied and Environmental Microbiology·Diana GutiérrezPilar García
Jul 25, 2013·Current Opinion in Microbiology·César de la Fuente-NúñezRobert E W Hancock
Dec 11, 2013·International Journal of Food Microbiology·Céline CampagnaSylvain Moineau
Jan 28, 2014·Applied and Environmental Microbiology·Anna Allué-GuardiaMaite Muniesa
Sep 10, 2014·PloS One·Diana GutiérrezPilar García
Mar 10, 2015·Applied and Environmental Microbiology·Diana GutiérrezPilar García
Jul 5, 2016·Frontiers in Microbiology·Diana GutiérrezPilar García
Feb 18, 2017·Frontiers in Microbiology·Stephen HayesDouwe Van Sinderen
Oct 11, 2017·Current Opinion in Biotechnology·Alessandra Gonçalves de MeloSylvain Moineau
Nov 9, 2017·Antibiotics·Lucía FernándezAna Rodríguez

❮ Previous
Next ❯

Citations

Jul 20, 2019·Expert Review of Anti-infective Therapy·Ewa Jończyk-MatysiakAndrzej Górski
Sep 7, 2018·Frontiers in Cellular and Infection Microbiology·Lucía FernándezPilar García
Feb 7, 2019·Frontiers in Microbiology·Diana GutiérrezPilar García
May 31, 2020·FEMS Microbiology Reviews·Diana P PiresJoana Azeredo
Feb 13, 2021·Antibiotics·Christian KranjecDzung B Diep
Jun 3, 2021·Viruses·Ari KauppinenIlkka T Miettinen
Mar 30, 2019·Accounts of Chemical Research·Jacques MathieuPedro J J Alvarez
Jun 30, 2021·Annual Review of Virology·Diana P PiresJoana Azeredo
Sep 7, 2021·Journal of the Science of Food and Agriculture·Jian LiQi Zhao

❮ Previous
Next ❯

Software Mentioned

RODI

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
L N Nesterenko, V S Zueva
The CLAO Journal : Official Publication of the Contact Lens Association of Ophthalmologists, Inc
R Whalen, L Janoff
© 2022 Meta ULC. All rights reserved