Study of the keratin-based therapeutic dermal patches for the delivery of bioactive molecules for wound treatment

Materials Science & Engineering. C, Materials for Biological Applications
Kush Kumar Nayak, Pratima Gupta

Abstract

In the present study, dressing materials were fabricated in the form of dermal patches. The keratin based biocompatible materials, namely Keratin/Alginate, Keratin/Agar, and Keratin/Gellan were developed as therapeutic dermal patches. The patches were coated with green synthesized silver nanoparticles to prevent the microbial infection and were found to be antimicrobial against pathogens. Papain was used in the patches to acquire the enzymatic cell debridement and its activity was measured by reduction rate of benzoyl-l-arginine ethyl ester. Glucose oxidase was loaded into the patches and examined to control the glycemic level in vitro for its topical application. For better wound healing, the patches were loaded with Trolox® to incorporate antioxidant properties. The patches were found mechanically efficient to sustain the material during application. The porosity and water absorption capacity of the dermal patches were investigated to ensure the maintenance of the optimum environment essential for wound treatment. To achieve the regeneration of the skin layer during wound healing, the fibroblast growth factor was loaded in the patches and it was observed that 77.77-88.89% of growth factor were released after three days of stu...Continue Reading

Citations

Feb 23, 2019·Materials·Alexandra Muñoz-BonillaMarta Fernández-García
Jan 19, 2019·Oncology Letters·Xiaoqiu ZhouXingong Li
Dec 7, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C Chocarro-WronaJ A Marchal
Apr 24, 2020·Bioactive Materials·Sandleen FerozGeorge Dias
Mar 12, 2021·Journal of Biomaterials Science. Polymer Edition·Rajat Anand, Awanish Kumar
Nov 1, 2020·International Journal of Biological Macromolecules·Niédja Fittipaldi VasconcelosFábia Karine Andrade

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