Study of the metabolism of phenothiazines: determination of N-demethylated phenothiazines in urine

Journal of Analytical Toxicology
H Y ChooJ Park

Abstract

When phenothiazine drugs (chlorpromazine, promazine, promethazine, propiomazine, propionylpromazine, trifluoperazine and trimeprazine) were reacted with m-chloroperbenzoic acid, N-demethylated phenothiazines were obtained in moderate yield. The mass spectra of the N-demethylated phenothiazines showed either m/z 44 and 72 or m/z 58 as characteristic ions depending on their side chain. The N-demethylated propiomazine was identified as a metabolite of propiomazine from the urine of a rat which was given propiomazine orally.

Related Concepts

3-chloroperbenzoic acid
Metazoa
Chlorobenzoic Acids
Chromatography, Gas-Liquid-Mass Spectrometry
Phenothiazines
August Rats
Antipsychotic Effect
Rats, Laboratory

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