Study of the murine allantois by allantoic explants

Developmental Biology
Karen M DownsJacalyn McHugh

Abstract

The murine allantois will become the umbilical artery and vein of the chorioallantoic placenta. In previous studies, growth and differentiation of the allantois had been elucidated in whole embryos. In this study, the extent to which explanted allantoises grow and differentiate outside of the conceptus was investigated. The explant model was then used to elucidate cell and growth factor requirements in allantoic development. Early headfold-stage murine allantoises were explanted directly onto tissue culture plastic or suspended in test tubes. Explanted allantoises vascularized with distal-to-proximal polarity, they exhibited many of the same signaling factors used by the vitelline and cardiovascular systems, and they contained at least three cell types whose identity, gene expression profiles, topographical associations, and behavior resembled those of intact allantoises. DiI labeling further revealed that isolated allantoises grew and vascularized in the absence of significant cell mingling, thereby supporting a model of mesodermal differentiation in the allantois that is position- and possibly age-dependent. Manipulation of allantoic explants by varying growth media demonstrated that the allantoic endothelial cell lineage, li...Continue Reading

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Citations

Jun 25, 2004·The American Journal of Pathology·Monica IurlaroElisabetta Dejana
Oct 15, 2011·Cells, Tissues, Organs·John C ChappellVictoria L Bautch
Nov 24, 2011·PloS One·Enrique ZudaireSonja Vermeren
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Feb 5, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karen M DownsAllen C Enders
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Carmine GentileChristopher J Drake
Jan 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karen M Downs
Nov 20, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maria M Mikedis, Karen M Downs
Mar 21, 2006·Gene Expression Patterns : GEP·Kimberly E Inman, Karen M Downs
Apr 12, 2002·Placenta·K M Downs
Oct 3, 2006·Developmental Biology·Catherine CorbelFrançoise Dieterlen-Lièvre
Aug 3, 2012·Blood·Ripla Arora, Virginia E Papaioannou
Jun 9, 2016·Development, Growth & Differentiation·Jiu-Zhen JinJixiang Ding
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Dec 29, 2009·Theriogenology·F HerrM Zygmunt
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Sep 21, 2004·The Journal of Biological Chemistry·Kelley M ArgravesChristopher J Drake
Jan 27, 2007·The EMBO Journal·Dirk SchmidtMarina Schorpp-Kistner
Mar 14, 2008·The EMBO Journal·Noemi RudiniElisabetta Dejana
Apr 19, 2007·Genesis : the Journal of Genetics and Development·Kimberly E Inman, Karen M Downs
May 13, 2005·Physiology·Erica D Watson, James C Cross
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Apr 22, 2010·Journal of Cell Science·Yuka SuzukiTetsuro Watabe
Jul 13, 2006·Development·Kimberly E Inman, Karen M Downs

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