PMID: 7932058Jun 1, 1994Paper

Study of the mutual effects of sulphadiazine and ciprofloxacin on their uptakes by Pseudomonas aeruginosa

The Journal of Pharmacy and Pharmacology
R M RichardsD K Xing


A high-performance liquid chromatography (HPLC) assay was developed for ciprofloxacin and sulphadiazine in Isosensitest broth. Combining the HPLC assay with cell dry-weight determinations indicated that both compounds were able to enhance the uptake of the other by log phase Pseudomonas aeruginosa cultured in the presence of the compounds. It is hypothesized that the increased bacterial uptakes are the reason for the enhanced antibacterial activity previously reported for combinations of ciprofloxacin and sulphadiazine.


Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H C Neu
Nov 30, 1989·The American Journal of Medicine·G M Eliopoulos, C T Eliopoulos
Apr 1, 1989·The Journal of Antimicrobial Chemotherapy·C Y ChanG L French
Mar 1, 1993·The Journal of Pharmacy and Pharmacology·R M Richards, D K Xing
Jan 1, 1993·Journal of Medical Microbiology·R M RichardsD Marshall

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Sep 1, 1996·The Journal of Pharmacy and Pharmacology·R M RichardsZ Y Zhu

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