PMID: 6400157Jan 1, 1984Paper

Study of the normal human kidney and kidney cancer with monoclonal antibodies

Uremia Investigation
N H Bander

Abstract

The ability to establish immortal tissue culture lines of human renal cancer as well as short-term lines of autologous normal kidney epithelium offers a unique system to probe the differences between a neoplastic cell and its normal counterpart. Monoclonal antibodies have been prepared against cell surface differentiation antigens of normal and neoplastic human kidney. The detected antigens have been biochemically characterized, and the molecular phenotypes of these cells is being unraveled. Differences in gene expression are becoming apparent between the normal and neoplastic kidney cell. Preliminary results indicate that these differences appear to have clinical significance.

References

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Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J G CairncrossL J Old
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Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R UedaL J Old
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Feb 27, 1980·Biochemical and Biophysical Research Communications·R ClaymanM E Dempsey

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Citations

Mar 1, 1991·Kidney International·C B Wilson

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