Study of the origins of melanin-concentrating hormone and neuropeptide EI immunoreactive projections to the periaqueductal gray matter

Brain Research
C F Elias, J C Bittencourt

Abstract

Previous studies have described the distribution of melanin-concentrating hormone (MCH) and neuropeptide EI (NEI) in the rat central nervous system (CNS), and revealed this peptidergic system to be primarily localized in neurons within the lateral hypothalamic area (LHA) and zona incerta (ZI). Moreover, an extensive MCH- and NEI-immunoreactive (ir) fiber distribution has been described throughout the CNS, including a dense innervation within the periaqueductal gray matter (PAG). MCH and NEI have become important markers for the LHA, which harbors a variety of neuronal types as well as the medial forebrain bundle, a complex system of fibers which extends rostrocaudally throughout this area. In the present study, the projection patterns of MCH- and NEI-ir fibers within the PAG were characterized using a diamino benzidine immunoperoxidase procedure to localize each of these peptides in normal rat brain sections. MCH- and NEI-ir fibers were seen coursing through all of its subdivisions the entire length of the PAG, with a more condensed number of fibers in the periaqueductal medial zone. The primary origin(s) of these PAG afferents were determined in combined retrograde tracing immunofluorescent studies in which true blue (TB) was ...Continue Reading

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Citations

Dec 8, 2006·Cellular and Molecular Neurobiology·Lucien F Harthoorn
Sep 5, 1998·Brain Research·C L MillerR C Thompson
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Newton S Canteras
Apr 6, 2011·General and Comparative Endocrinology·Jackson C Bittencourt
Jan 26, 2011·Neuroscience·B A KesslerJ Fadel
Dec 11, 2007·Journal of Chemical Neuroanatomy·C F EliasJ C Bittencourt
Apr 3, 2008·The European Journal of Neuroscience·Antoine AdamantidisPatrice Fort
Jan 27, 2015·Frontiers in Systems Neuroscience·Roda Rani KonadhodePriyattam J Shiromani
Dec 23, 2003·The Journal of Comparative Neurology·Claire E Heise, John Mitrofanis
May 20, 1999·The Journal of Comparative Neurology·N S Canteras, M Goto
Jun 3, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin
Jun 4, 2019·The Journal of Comparative Neurology·Giovanne B DinizJackson C Bittencourt
Sep 29, 2020·Frontiers in Neuroanatomy·Bethany G BeeklyCarol F Elias
Jun 15, 2017·Frontiers in Systems Neuroscience·Giovanne B Diniz, Jackson C Bittencourt

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