Study of the performance of three LC-MS/MS platforms for analysis of perfluorinated compounds

Analytical and Bioanalytical Chemistry
Marta LlorcaDamià Barceló

Abstract

The analytical suitabilities of three different liquid chromatography-tandem mass spectrometry (LC-MS/MS) systems, (1) triple quadrupole (QqQ), (2) conventional 3D ion trap (IT), and (3) quadrupole-linear IT (QqLIT), to determine trace levels of perfluorinated compounds (PFCs) in fish and shellfish were compared. Sample preparation was performed using alkaline extraction and solid-phase-extraction cleanup. This evaluation was focused on both quantitative (sensitivity, precision, and accuracy) and qualitative (identification capabilities) aspects. In the three instruments, the former facet was evaluated using selected reaction monitoring (SRM), which is the standard mode for quantitative LC-MS/MS analysis. Accuracy was similar in the three systems, with recoveries always over 70 %. Precision was better for the QqLIT and QqQ systems (7-15%) than for the IT system (10-17%). The QqLIT (working in SRM mode) and QqQ systems offered a linear dynamic range of at least 3 orders of magnitude, whereas that of the IT system was 2 orders of magnitude. The QqLIT system achieved at least 20-fold higher sensitivity than the QqQ system, and this was at least tenfold higher sensitivity than for the IT system. In the IT system, identification was...Continue Reading

References

May 2, 2001·Environmental Science & Technology·K KannanJ P Giesy
May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
Aug 17, 2001·Environmental Science & Technology·K KannanJ P Giesy
Jun 24, 2004·Environmental Science & Technology·Mary Joyce A DinglasanScott A Mabury
Aug 7, 2004·Environmental Science & Technology·Jonathan W MartinStefan van Leeuwen
Feb 10, 2006·International Journal of Andrology·Antonia M CalafatLarry L Needham
May 20, 2006·Analytical and Bioanalytical Chemistry·Marta VillagrasaDamià Barceló
Aug 12, 2006·Journal of Occupational and Environmental Medicine·Edward Anthony EmmettLeslie Michael Shaw
Mar 6, 2007·International Journal of Hygiene and Environmental Health·C SchulzM Kolossa-Gehring
Mar 23, 2007·International Journal of Hygiene and Environmental Health·Jürgen AngererMichael Wilhelm
Jan 19, 2008·Journal of Chromatography. a·John W WashingtonJohn J Evans
Jun 10, 2008·Ecotoxicology and Environmental Safety·Ilaria ColomboJacques L'Haridon
Jun 21, 2008·International Journal of Hygiene and Environmental Health·Hermann FrommeDorothee Twardella
Aug 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xingguo Cheng, Curtis D Klaassen
Apr 16, 2010·Journal of Chromatography. a·Ashok Kumar MalikYolanda Picó
May 25, 2010·Environment International·Marta LlorcaDamià Barceló

❮ Previous
Next ❯

Citations

Oct 31, 2012·Analytical and Bioanalytical Chemistry·Sara ValsecchiStefano Polesello
May 1, 2012·Environmental Science and Pollution Research International·Alícia Navarro-OrtegaDamià Barceló
Jul 29, 2011·Critical Reviews in Food Science and Nutrition·Yolanda PicóDamià Barceló

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.