PMID: 15357186Sep 11, 2004Paper

Study of the point spread function (PSF) for 123I SPECT imaging using Monte Carlo simulation

Physics in Medicine and Biology
A CotD Ros

Abstract

The iterative reconstruction algorithms employed in brain single-photon emission computed tomography (SPECT) allow some quantitative parameters of the image to be improved. These algorithms require accurate modelling of the so-called point spread function (PSF). Nowadays, most in vivo neurotransmitter SPECT studies employ pharmaceuticals radiolabelled with 123I. In addition to an intense line at 159 keV, the decay scheme of this radioisotope includes some higher energy gammas which may have a non-negligible contribution to the PSF. The aim of this work is to study this contribution for two low-energy high-resolution collimator configurations, namely, the parallel and the fan beam. The transport of radiation through the material system is simulated with the Monte Carlo code PENELOPE. We have developed a main program that deals with the intricacies associated with tracking photon trajectories through the geometry of the collimator and detection systems. The simulated PSFs are partly validated with a set of experimental measurements that use the 511 keV annihilation photons emitted by a 18F source. Sensitivity and spatial resolution have been studied, showing that a significant fraction of the detection events in the energy window...Continue Reading

References

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Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Deborah ParetoDomènec Ros
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Citations

Sep 14, 2006·Medical Physics·Aldo BadanoJosep Sempau
Dec 14, 2007·Medical Physics·Aldo BadanoJosep Sempau
Apr 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Livia Tossici-BoltAndrea Varrone
May 14, 2009·IEEE Transactions on Medical Imaging·Andreu BadalJosep Sempau
Mar 11, 2009·IEEE Transactions on Medical Imaging·Aldo BadanoJosep Sempau
May 17, 2007·Physics in Medicine and Biology·Steven StaelensFreek Beekman
Sep 21, 2007·Physics in Medicine and Biology·Predrag MarinkovicRajko Spaic
Mar 3, 2006·Physics in Medicine and Biology·Aldo Badano, Josep Sempau
Mar 20, 2018·Physics in Medicine and Biology·Aida Niñerola-BaizánDomènec Ros
Jun 28, 2011·Physics in Medicine and Biology·Brian F HuttonFreek J Beekman

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