STUDY OF THE ROLE OF SERUM FOLIC ACID IN ATOPIC DERMATITIS: A CORRELATION WITH SERUM IgE AND DISEASE SEVERITY.

Indian Journal of Dermatology
Maha A ShaheenNashwa Bareedy

Abstract

Most atopic dermatitis (AD) patients have elevated serum immunoglobulin E (IgE). Impaired folic acid (FA) metabolism was found to reduce the intracellular methyl donor pool, associated with a higher prevalence of atopy. To assess serum IgE and FA in AD patients and to correlate their levels with the disease severity, and with each other. Twenty patients with AD were assessed for serum FA and IgE, compared with 20 age- and sex-matched controls. Patients were classified into three groups (mild, moderate, and severe AD) based on clinical severity according to Nottingham index. In both patients and controls, serum IgE was measured using Enzyme-linked immunosorbent assay technique and serum FA was measured using Microparticle Enzyme Immunoassay technique. Serum FA levels were lower in AD patients compared with controls, but the difference was not statistically significant. FA levels did not show statistically significant difference among disease severity groups and did not correlate with serum IgE levels. On the other hand, serum IgE levels were significantly elevated in AD patients compared with controls, and among AD patients, its levels were significantly elevated in severe AD compared with mild and moderate disease. Serum IgE is...Continue Reading

Citations

May 9, 2013·American Journal of Respiratory and Critical Care Medicine·Joshua BlatterJuan C Celedón
Sep 4, 2015·Allergy, Asthma & Immunology Research·Ting WangGang Wang
Dec 24, 2013·The Journal of Allergy and Clinical Immunology·Sunita Sharma, Augusto Litonjua
Feb 1, 2021·The Journal of Allergy and Clinical Immunology·Yael Renert-YuvalEmma Guttman-Yassky

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Methods Mentioned

BETA
Enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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